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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Histone-lysine N-methyltransferase EZH2 | ||
| Ligand | BDBM574919 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ZH2 biochemical assay (IC50) | ||
| IC50 | 0.5±n/a nM | ||
| Citation |  Brenneman, JB; Côté, A; Gehling, VS; Khanna, A; Levell, JR; Moine, L Modulators of methyl modifying enzymes, compositions and uses thereof US Patent US11459315 Publication Date 10/4/2022 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Histone-lysine N-methyltransferase EZH2 | |||
| Name: | Histone-lysine N-methyltransferase EZH2 | ||
| Synonyms: | ENX-1 | EZH2 | EZH2_HUMAN | Enhancer of zeste homolog 2 (EZH2) | Histone-lysine N-methyltransferase EZH2 | KMT6 | Lysine N-methyltransferase 6 | ||
| Type: | Protein | ||
| Mol. Mass.: | 85367.84 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q15910 | ||
| Residue: | 746 | ||
| Sequence: |
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| BDBM574919 | |||
| n/a | |||
| Name | BDBM574919 | ||
| Synonyms: | 6-methyl-N-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3-yl)methyl)-7-((R)-1-(4-(oxetan-3-ylamino)cyclohexyl)ethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide | US11459315, Example 63 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H36N6O3S | ||
| Mol. Mass. | 524.678 | ||
| SMILES | CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)C2CCC(CC2)NC2COC2)c2ncncc12 |wU:18.19,(2.54,-2.14,;4.03,-2.54,;4.42,-4.02,;5.91,-4.42,;6.31,-5.91,;7.8,-6.31,;5.22,-7,;3.73,-6.6,;2.64,-7.69,;3.33,-5.11,;1.85,-4.71,;1.45,-3.23,;-.04,-2.83,;-1.13,-3.92,;-.51,-1.36,;.39,-.12,;1.93,-.12,;-.51,1.13,;-.04,2.59,;1.47,2.91,;-1.07,3.74,;-2.58,3.42,;-3.61,4.56,;-3.13,6.03,;-1.62,6.35,;-.59,5.2,;-4.16,7.17,;-5.67,6.85,;-6.96,7.69,;-7.8,6.4,;-6.51,5.56,;-1.98,.65,;-3.31,1.42,;-4.65,.65,;-4.65,-.89,;-3.31,-1.66,;-1.98,-.89,)| | ||
| Structure | 
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