Reaction Details |
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Target | Isoform Tau-F of Microtubule-associated protein tau |
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Ligand | BDBM576623 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ALA Assay |
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IC50 | 17100±n/a nM |
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Citation | Davidowitz, EJ; Moe, JG; Reitz, AB; Bian, H; Gluchowski, C; Hendrix, J; Yehaskel, AS; McDonnell, ME; Loughran, HM Quinazolinones that inhibit the formation of tau oligomers and their method of use US Patent US11472776 Publication Date 10/18/2022 |
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More Info.: | Get all data from this article, Assay Method |
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Isoform Tau-F of Microtubule-associated protein tau |
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Name: | Isoform Tau-F of Microtubule-associated protein tau |
Synonyms: | MAPT | MAPTL | MTBT1 | Microtubule-associated protein | Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R) | Microtubule-associated protein tau (TAU)(2N4R) | TAU | TAU_HUMAN |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 45857.42 |
Organism: | Homo sapiens (Human) |
Description: | P10636-8 |
Residue: | 441 |
Sequence: | MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPG
SETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAG
HVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPK
TPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAK
SRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHV
PGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNI
THVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMV
DSPQLATLADEVSASLAKQGL
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BDBM576623 |
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n/a |
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Name | BDBM576623 |
Synonyms: | US11472776, Example 11 |
Type | Small organic molecule |
Emp. Form. | C18H13N3O2S |
Mol. Mass. | 335.38 |
SMILES | Cc1ccc(cc1O)-n1c(nc2ccsc2c1=O)-c1cccnc1 |
Structure |
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