| Reaction Details |
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 | Report a problem with these data |
| Target | Isoform Tau-F of Microtubule-associated protein tau |
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| Ligand | BDBM576626 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ALA Assay |
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| IC50 | 3720±n/a nM |
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| Citation |  Davidowitz, EJ; Moe, JG; Reitz, AB; Bian, H; Gluchowski, C; Hendrix, J; Yehaskel, AS; McDonnell, ME; Loughran, HM Quinazolinones that inhibit the formation of tau oligomers and their method of use US Patent US11472776 Publication Date 10/18/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Isoform Tau-F of Microtubule-associated protein tau |
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| Name: | Isoform Tau-F of Microtubule-associated protein tau |
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| Synonyms: | MAPT | MAPTL | MTBT1 | Microtubule-associated protein | Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R) | Microtubule-associated protein tau (TAU)(2N4R) | TAU | TAU_HUMAN |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 45857.42 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P10636-8 |
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| Residue: | 441 |
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| Sequence: | MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPG
SETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAG
HVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPK
TPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAK
SRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHV
PGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNI
THVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMV
DSPQLATLADEVSASLAKQGL
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| BDBM576626 |
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| n/a |
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| Name | BDBM576626 |
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| Synonyms: | US11472776, Example 15 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H7N3OS |
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| Mol. Mass. | 229.258 |
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| SMILES | O=c1[nH]c(nc2ccsc12)-c1cccnc1 |
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| Structure | 
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