Ki Summary

Reaction Details

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Target

Non-receptor tyrosine-protein kinase TYK2

Ligand

BDBM577199

Substrate/Competitor

n/a

Meas. Tech.

JAK Caliper Enzyme Assay at 1 mM ATP

IC50

21.0±n/a nM

Citation

Brown, MF; Dermenci, A; Fensome, A; Gerstenberger, BS; Hayward, MM; Owen, DR; Wright, SW; Xing, LH; Yang, X Pyrazolo[1,5-a]pyrazin-4-yl derivatives US Patent US11472809 Publication Date 10/18/2022

More Info.:

Get all data from this article, Assay Method

Non-receptor tyrosine-protein kinase TYK2

Name:

Non-receptor tyrosine-protein kinase TYK2

Synonyms:

Non-receptor tyrosine-protein kinase TYK2 (TYK2) | TYK2 | TYK2_HUMAN | Tyrosine-protein kinase TYK2

Type:

Protein

Mol. Mass.:

133666.03

Organism:

Homo sapiens (Human)

Description:

P29597

Residue:

1187

Sequence:

MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHI
AHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREP
AVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFK
NESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRR
FLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAP
TDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHK
AVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLV
DGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHP
YRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRA
GDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTR
TNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETAS
LMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLAS
ALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLA
PECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQ
LATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKI
RDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHII
KYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYI
HRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYY
ASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKC
PCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC

BDBM577199

n/a

Name

BDBM577199

Synonyms:

5-(4-(1-((1r,3s)-1-(Cyanomethyl)-3-methoxycyclobutyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-6-yl)-N-methyl-1H-pyrazole-3-carboxamide | US11472809, Example 6

Type

Small organic molecule

Emp. Form.

C21H22N9O2

Mol. Mass.

432.4585

SMILES

CNC(=O)c1cc([nH]n1)-c1cn2nccc2c(n1)C1=CN[N](=C1)[C@@]1(CC#N)C[C@@H](C1)OC |r,wU:23.26,wD:28.34,c:24,t:21,(7.76,-5.97,;6.23,-6.13,;5.32,-4.88,;5.95,-3.48,;3.79,-5.04,;2.76,-3.9,;1.35,-4.53,;1.51,-6.06,;3.02,-6.38,;.02,-3.76,;-1.31,-4.53,;-2.65,-3.76,;-4.11,-4.23,;-5.02,-2.99,;-4.11,-1.74,;-2.65,-2.22,;-1.31,-1.45,;.02,-2.22,;-1.31,.09,;-.07,1,;-.54,2.46,;-2.08,2.46,;-2.56,1,;-2.99,3.71,;-1.45,3.71,;-.68,5.04,;.09,6.38,;-4.32,2.94,;-5.09,4.27,;-3.76,5.04,;-6.43,5.04,;-7.76,4.27,)|

Structure