| Reaction Details |
|---|
 | Report a problem with these data |
| Target | hek293 luciferase |
|---|
| Ligand | BDBM578519 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | HEK293 luciferase |
|---|
| EC50 | 132±n/a nM |
|---|
| Citation |  Bartholomeus, J; Bürli, R; Jarvis, R; Johnstone, S; Ostenfeld, T; Terstiege, I; Travagli, M; Turcotte, S Small molecule modulators of the BTB domain of Keap1 US Patent US11479539 Publication Date 10/25/2022 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| hek293 luciferase |
|---|
| Name: | Gag-Pol polyprotein [588-1147,M628L,D654N,M771V,L797W,T802Y] |
|---|
| Synonyms: | HIV RT (41L/67N/210W/215Y/184V) | POL_HV1H2 | gag-pol |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 64571.45 |
|---|
| Organism: | Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) |
|---|
| Description: | P04585[588-1147,M628L,D654N,M771V,L797W,T802Y] |
|---|
| Residue: | 560 |
|---|
| Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIGQHRTKIEELRQHLWRWGLYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVL
|
|
|
|---|
| BDBM578519 |
|---|
| n/a |
|---|
| Name | BDBM578519 |
|---|
| Synonyms: | (S)-3-methoxy- 5,5-dimethyl-3- (5-methylthiazol- 4-yl)-6- oxocyclohex-1- enecarbonitrile | US11479539, Compound 38 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H16N2O2S |
|---|
| Mol. Mass. | 276.354 |
|---|
| SMILES | CO[C@]1(CC(C)(C)C(=O)C(=C1)C#N)c1ncsc1C |r,c:9| |
|---|
| Structure | 
|
|---|
Search and Browse
