| Reaction Details |
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 | Report a problem with these data |
| Target | Kappa-type opioid receptor |
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| Ligand | BDBM579540 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Radioligand Binding Assay |
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| Ki | 3.70±n/a nM |
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| Citation |  Shoichet, BK; Lin, H; Gmeiner, P; Manglik, A; Kobilka, B; Roth, BL; Dengler, DG Mu opioid receptor modulators US Patent US11484525 Publication Date 11/1/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Kappa-type opioid receptor |
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| Name: | Kappa-type opioid receptor |
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| Synonyms: | K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 42648.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41145 |
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| Residue: | 380 |
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| Sequence: | MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRV
RNTVQDPAYLRDIDGMNKPV
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|
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| BDBM579540 |
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| n/a |
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| Name | BDBM579540 |
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| Synonyms: | US11484525, Compound DD-120-D1-covalent-compound |
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| Type | Small organic molecule |
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| Emp. Form. | C18H24N4O4 |
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| Mol. Mass. | 360.4076 |
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| SMILES | CN(C)[C@H](CNC(=O)NCCN1C(=O)C=CC1=O)Cc1ccc(O)cc1 |r,c:14| |
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| Structure | 
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