Ki Summary

Reaction Details

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Target

Monoglyceride lipase

Ligand

BDBM581597

Substrate/Competitor

n/a

Meas. Tech.

Biological Assay

IC50

0.048±n/a nM

Citation

Alcazar, J; Ameriks, MK; Berry, CB; Garcia-Reynaga, P; Samant, AV; Vega-Ramiro, JA Azaspirocycles as monoacylglycerol lipase modulators US Patent US11505546 Publication Date 11/22/2022

More Info.:

Get all data from this article, Assay Method

Monoglyceride lipase

Name:

Monoglyceride lipase

Synonyms:

Type:

Hydrolase

Mol. Mass.:

33264.56

Organism:

Homo sapiens (Human)

Description:

Human recombinant MGL (Cayman Chemical, cat# 10008354).

Residue:

303

Sequence:

MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEE
LARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLG
HSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPID
SSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADR
LCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTA
SPP

BDBM581597

n/a

Name

BDBM581597

Synonyms:

(2s,4s)-2-[2-(2,4-Dimethylphenyl)-7-azaspiro[3.5]nonane-7-carbonyl)-7-oxa-5- azaspiro[3.4]octan-6-one | US11505546, Example 12

Type

Small organic molecule

Emp. Form.

C23H30N2O3

Mol. Mass.

382.4959

SMILES

Cc1ccc(C2CC3(C2)CCN(CC3)C(=O)[C@H]2C[C@@]3(C2)COC(=O)N3)c(C)c1 |r,wU:16.17,wD:18.20,(9.15,-4.01,;7.82,-3.24,;7.82,-1.7,;6.48,-.93,;5.15,-1.7,;3.81,-.93,;2.33,-1.33,;1.93,.16,;3.42,.56,;.59,-.61,;-.74,.16,;-.74,1.7,;.59,2.47,;1.93,1.7,;-2.07,2.47,;-2.07,4.01,;-3.41,1.7,;-3.8,.21,;-5.29,.61,;-4.89,2.1,;-5.29,-.93,;-6.76,-1.41,;-7.66,-.16,;-9.15,.24,;-6.76,1.09,;5.15,-3.24,;3.81,-4.01,;6.48,-4.01,)|

Structure