Reaction Details | |||
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Report a problem with these data | |||
Target | Monoglyceride lipase | ||
Ligand | BDBM581599 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Biological Assay | ||
IC50 | 0.027±n/a nM | ||
Citation | Alcazar, J; Ameriks, MK; Berry, CB; Garcia-Reynaga, P; Samant, AV; Vega-Ramiro, JA Azaspirocycles as monoacylglycerol lipase modulators US Patent US11505546 Publication Date 11/22/2022 | ||
More Info.: | Get all data from this article, Assay Method | ||
Monoglyceride lipase | |||
Name: | Monoglyceride lipase | ||
Synonyms: | HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN | ||
Type: | Hydrolase | ||
Mol. Mass.: | 33264.56 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Human recombinant MGL (Cayman Chemical, cat# 10008354). | ||
Residue: | 303 | ||
Sequence: |
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BDBM581599 | |||
n/a | |||
Name | BDBM581599 | ||
Synonyms: | (2r,4s)-2-(2-(5-(tert-Butyl)-2-methylphenyl)-7-azaspiro[3.5]nonane-7-carbonyl)-5- azaspiro[3.4]octan-6-one | US11505546, Example 14 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H36N2O3 | ||
Mol. Mass. | 424.5756 | ||
SMILES | Cc1ccc(cc1C1CC2(C1)CCN(CC2)C(=O)[C@H]1C[C@@]2(C1)COC(=O)N2)C(C)(C)C |r,wU:18.20,wD:20.23,(3.21,-4.01,;4.54,-3.24,;5.88,-4.01,;7.21,-3.24,;7.21,-1.7,;5.88,-.93,;4.54,-1.7,;3.21,-.93,;1.72,-1.33,;1.32,.16,;2.81,.56,;-.01,-.61,;-1.35,.16,;-1.35,1.7,;-.01,2.47,;1.32,1.7,;-2.68,2.47,;-2.68,4.01,;-4.01,1.7,;-4.41,.21,;-5.9,.61,;-5.5,2.1,;-6.06,-.92,;-7.57,-1.24,;-8.34,.09,;-9.88,.09,;-7.31,1.24,;8.54,-.93,;9.88,-.16,;8.54,.61,;9.88,-1.7,)| | ||
Structure |