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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Monoglyceride lipase | ||
| Ligand | BDBM581638 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Biological Assay | ||
| IC50 | 0.710±n/a nM | ||
| Citation |  Alcazar, J; Ameriks, MK; Berry, CB; Garcia-Reynaga, P; Samant, AV; Vega-Ramiro, JA Azaspirocycles as monoacylglycerol lipase modulators US Patent US11505546 Publication Date 11/22/2022 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Monoglyceride lipase | |||
| Name: | Monoglyceride lipase | ||
| Synonyms: | HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN | ||
| Type: | Hydrolase | ||
| Mol. Mass.: | 33264.56 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Human recombinant MGL (Cayman Chemical, cat# 10008354). | ||
| Residue: | 303 | ||
| Sequence: |
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| BDBM581638 | |||
| n/a | |||
| Name | BDBM581638 | ||
| Synonyms: | (rac)-(2s,4s)-2-(6-Cyclohexyl-2-azaspiro[3.4]octane-2-carbonyl)-7-oxa-5- azaspiro[3.4]octan-6-one | US11505546, Example 53 | US11505546, Example 54 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H30N2O3 | ||
| Mol. Mass. | 346.4638 | ||
| SMILES | O=C([C@H]1C[C@@]2(C1)COC(=O)N2)N1CC2(C1)CCC(C2)C1CCCCC1 |r,wU:2.1,wD:4.4,(-1.44,2.88,;-1.44,1.34,;-2.85,.71,;-3.25,-.77,;-4.73,-.37,;-4.33,1.11,;-4.65,-1.91,;-6.09,-2.46,;-7.06,-1.27,;-8.55,-1.06,;-6.22,.02,;-.19,.44,;1.33,.68,;1.57,-.84,;.05,-1.09,;1.57,-2.38,;3.03,-2.86,;3.94,-1.61,;3.03,-.37,;5.48,-1.61,;6.35,-2.88,;7.89,-2.76,;8.55,-1.37,;7.67,-.1,;6.14,-.22,)| | ||
| Structure | 
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