Reaction Details | |||
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Target | Monoglyceride lipase | ||
Ligand | BDBM581648 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Biological Assay | ||
IC50 | 0.100±n/a nM | ||
Citation | Alcazar, J; Ameriks, MK; Berry, CB; Garcia-Reynaga, P; Samant, AV; Vega-Ramiro, JA Azaspirocycles as monoacylglycerol lipase modulators US Patent US11505546 Publication Date 11/22/2022 | ||
More Info.: | Get all data from this article, Assay Method | ||
Monoglyceride lipase | |||
Name: | Monoglyceride lipase | ||
Synonyms: | HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN | ||
Type: | Hydrolase | ||
Mol. Mass.: | 33264.56 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Human recombinant MGL (Cayman Chemical, cat# 10008354). | ||
Residue: | 303 | ||
Sequence: |
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BDBM581648 | |||
n/a | |||
Name | BDBM581648 | ||
Synonyms: | (rac)-(2s,4s)-2-(6-(4-Isopropylphenyl)-2-azaspiro[3.4]octane-2-carbonyl)-7-oxa-5- azaspiro[3.4]octan-6-one | US11505546, Example 63 | ||
Type | Small organic molecule | ||
Emp. Form. | C23H30N2O3 | ||
Mol. Mass. | 382.4959 | ||
SMILES | CC(C)c1ccc(cc1)C1CCC2(CN(C2)C(=O)[C@H]2C[C@@]3(C2)COC(=O)N3)C1 |r,wU:18.19,wD:20.22,(9.62,.42,;8.95,-.97,;9.82,-2.24,;7.41,-1.08,;6.74,-2.47,;5.21,-2.58,;4.34,-1.31,;5.01,.08,;6.55,.19,;2.81,-1.42,;1.9,-2.67,;.44,-2.19,;.44,-.65,;-1.05,-1.05,;-1.45,.43,;.04,.83,;-2.78,1.2,;-2.78,2.74,;-4.12,.43,;-4.52,-1.05,;-6,-.65,;-5.6,.83,;-5.92,-2.19,;-7.36,-2.74,;-8.33,-1.55,;-9.82,-1.41,;-7.49,-.26,;1.9,-.18,)| | ||
Structure |