Ki Summary

Reaction Details

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Target

Monoglyceride lipase

Ligand

BDBM581654

Substrate/Competitor

n/a

Meas. Tech.

Biological Assay

IC50

0.900±n/a nM

Citation

Alcazar, J; Ameriks, MK; Berry, CB; Garcia-Reynaga, P; Samant, AV; Vega-Ramiro, JA Azaspirocycles as monoacylglycerol lipase modulators US Patent US11505546 Publication Date 11/22/2022

More Info.:

Get all data from this article, Assay Method

Monoglyceride lipase

Name:

Monoglyceride lipase

Synonyms:

Type:

Hydrolase

Mol. Mass.:

33264.56

Organism:

Homo sapiens (Human)

Description:

Human recombinant MGL (Cayman Chemical, cat# 10008354).

Residue:

303

Sequence:

MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEE
LARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLG
HSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPID
SSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADR
LCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTA
SPP

BDBM581654

n/a

Name

BDBM581654

Synonyms:

(2s,4s)-2-(6-Cyclohexyl-2-azaspiro[3.3]heptane-2-carbonyl)-7-oxa-5- azaspiro[3.4]octan-6-one | US11505546, Example 69

Type

Small organic molecule

Emp. Form.

C19H28N2O3

Mol. Mass.

332.4372

SMILES

O=C([C@H]1C[C@@]2(C1)COC(=O)N2)N1CC2(CC(C2)C2CCCCC2)C1 |r,wU:2.1,wD:4.4,(-1.04,3.78,;-1.04,2.24,;-2.37,1.47,;-2.77,-.01,;-4.26,.39,;-3.86,1.87,;-4.18,-1.15,;-5.61,-1.7,;-6.58,-.51,;-8.07,-.3,;-5.74,.78,;.3,1.47,;.7,-.01,;2.18,.38,;2.58,-1.1,;4.07,-.7,;3.67,.78,;5.4,-1.47,;5.4,-3.01,;6.74,-3.78,;8.07,-3.01,;8.07,-1.47,;6.74,-.7,;1.78,1.87,)|

Structure