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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Monoglyceride lipase | ||
| Ligand | BDBM581658 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Biological Assay | ||
| IC50 | 0.210±n/a nM | ||
| Citation |  Alcazar, J; Ameriks, MK; Berry, CB; Garcia-Reynaga, P; Samant, AV; Vega-Ramiro, JA Azaspirocycles as monoacylglycerol lipase modulators US Patent US11505546 Publication Date 11/22/2022 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Monoglyceride lipase | |||
| Name: | Monoglyceride lipase | ||
| Synonyms: | HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN | ||
| Type: | Hydrolase | ||
| Mol. Mass.: | 33264.56 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Human recombinant MGL (Cayman Chemical, cat# 10008354). | ||
| Residue: | 303 | ||
| Sequence: |
| ||
| BDBM581658 | |||
| n/a | |||
| Name | BDBM581658 | ||
| Synonyms: | (2s,4s)-2-(6-(3-Cyclobutylphenyl)-2-azaspiro[3.3]heptane-2-carbonyl)-7-oxa-5- azaspiro[3.4]octan-6-one | US11505546, Example 73 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H28N2O3 | ||
| Mol. Mass. | 380.48 | ||
| SMILES | O=C([C@H]1C[C@@]2(C1)COC(=O)N2)N1CC2(CC(C2)c2cccc(c2)C2CCC2)C1 |r,wU:2.1,wD:4.4,(-2.62,3.78,;-2.62,2.24,;-3.95,1.47,;-4.35,-.01,;-5.84,.39,;-5.44,1.87,;-5.76,-1.15,;-7.2,-1.7,;-8.17,-.51,;-9.71,-.51,;-7.33,.78,;-1.29,1.47,;-.89,-.01,;.6,.38,;1,-1.1,;2.49,-.7,;2.09,.78,;3.82,-1.47,;3.82,-3.01,;5.15,-3.78,;6.49,-3.01,;6.49,-1.47,;5.15,-.7,;7.82,-.7,;9.31,-1.1,;9.71,.38,;8.22,.78,;.2,1.87,)| | ||
| Structure | 
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