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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Monoglyceride lipase | ||
| Ligand | BDBM581659 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Biological Assay | ||
| IC50 | 0.620±n/a nM | ||
| Citation |  Alcazar, J; Ameriks, MK; Berry, CB; Garcia-Reynaga, P; Samant, AV; Vega-Ramiro, JA Azaspirocycles as monoacylglycerol lipase modulators US Patent US11505546 Publication Date 11/22/2022 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Monoglyceride lipase | |||
| Name: | Monoglyceride lipase | ||
| Synonyms: | HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN | ||
| Type: | Hydrolase | ||
| Mol. Mass.: | 33264.56 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Human recombinant MGL (Cayman Chemical, cat# 10008354). | ||
| Residue: | 303 | ||
| Sequence: |
| ||
| BDBM581659 | |||
| n/a | |||
| Name | BDBM581659 | ||
| Synonyms: | (2s,4s)-2-(6-(2,3-Dihydro-1H-inden-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl)-7- oxa-5-azaspiro[3.4]octan-6-one | US11505546, Example 74 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H26N2O3 | ||
| Mol. Mass. | 366.4534 | ||
| SMILES | O=C([C@H]1C[C@@]2(C1)COC(=O)N2)N1CC2(CC(C2)c2ccc3CCCc3c2)C1 |r,wU:2.1,wD:4.4,(-2.14,3.78,;-2.14,2.24,;-3.48,1.47,;-3.88,-.01,;-5.36,.39,;-4.97,1.87,;-5.52,-1.15,;-7.03,-1.47,;-7.8,-.13,;-9.33,.03,;-6.77,1.01,;-.81,1.47,;.68,1.87,;1.08,.39,;2.56,.78,;2.96,-.7,;1.47,-1.1,;4.3,-1.47,;4.3,-3.01,;5.63,-3.78,;6.96,-3.01,;8.43,-3.49,;9.33,-2.24,;8.43,-1,;6.96,-1.47,;5.63,-.7,;-.41,-.01,)| | ||
| Structure | 
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