| Reaction Details |
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 | Report a problem with these data |
| Target | Gamma-aminobutyric acid (GABA) B receptor 1 |
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| Ligand | BDBM585859 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TBD |
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| IC50 | <10±n/a nM |
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| Citation |  Martinez Botella, G; Salituro, FG; Robichaud, AJ; Harrison, BL Compositions and methods for treating CNS disorders US Patent US11530237 Publication Date 12/20/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Gamma-aminobutyric acid (GABA) B receptor 1 |
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| Name: | Gamma-aminobutyric acid (GABA) B receptor 1 |
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| Synonyms: | GABA-B receptor 1 | GABA-B-R1 | Gamma-aminobutyric acid type B receptor subunit 1 (GABA) | Gb1 | gamma-Aminobutyric Acid Type B Receptor Subunit 1 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 108221.06 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Q6MFX8 |
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| Residue: | 960 |
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| Sequence: | MLLLLLVPLFLRPLGAGGAQTPNATSEGCQIIHPPWEGGIRYRGLTRDQVKAINFLPVDY
EIEYVCRGEREVVGPKVRKCLANGSWTDMDTPSRCVRICSKSYLTLENGKVFLTGGDLPA
LDGARVEFRCDPDFHLVGSSRSVCSQGQWSTPKPHCQVNRTPHSERRAVYIGALFPMSGG
WPGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKII
LMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLF
EKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARI
IVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKTYDPSINCTVEEMTEAVEG
HITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKRHPEETGGFQEAPLAYDAIWALALAL
NKTSGGGGRSGVRLEDFNYNNQTITDQIYRAMNSSSFEGVSGHVVFDASGSRMAWTLIEQ
LQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSPPADQTLVIKTFRFLSQKLFISVSVLSSL
GIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRSQFPF
VCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMD
VLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSKKMNTWLGIFYGYKGLLL
LLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLAI
VFSSYITLVVLFVPKMRRLITRGEWQSETQDTMKTGSSTNNNEEEKSRLLEKENRELEKI
IAEKEERVSELRHQLQSRQQLRSRRHPPTPPDPSGGLPRGPSEPPDRLSCDGSRVHLLYK
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| BDBM585859 |
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| n/a |
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| Name | BDBM585859 |
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| Synonyms: | US11530237, Compound 15 | US11542297, Compound 15 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H41N3O3 |
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| Mol. Mass. | 479.6541 |
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| SMILES | COc1ccc2n(CC(=O)[C@H]3CC[C@H]4[C@@H]5CC[C@@H]6C[C@](C)(O)CC[C@]6(C)[C@H]5CC[C@]34C)nnc2c1 |r| |
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| Structure | 
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