Ki Summary

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Target

Mitogen-activated protein kinase kinase kinase kinase 1

Ligand

BDBM587483

Substrate/Competitor

n/a

Meas. Tech.

MAP4K1 Biochemical Enzymatic Activity Assay

IC50

0.100±n/a nM

Citation

Brubaker, JD; Miduturu, CV; Burke, MJ; Dineen, TA; Kim, JL; Close, JT; Perola, E MAP4K1 inhibitors US Patent US11534441 Publication Date 12/27/2022

More Info.:

Get all data from this article, Assay Method

Mitogen-activated protein kinase kinase kinase kinase 1

Name:

Mitogen-activated protein kinase kinase kinase kinase 1

Synonyms:

HPK1 | M4K1_HUMAN | MAP4K1

Type:

PROTEIN

Mol. Mass.:

91316.07

Organism:

Homo sapiens (Human)

Description:

ChEMBL_586597

Residue:

833

Sequence:

MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQ
KEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCRE
VLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMA
PEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK
GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI
GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP
PRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQL
SPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMK
RKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPS
RTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTK
IQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVF
ALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDM
VMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQ
LLQELRDPTLTFRLLGSPRLECSGTISPHCNLLLPGSSNSPASASRVAGITGL

BDBM587483

n/a

Name

BDBM587483

Synonyms:

US11534441, Compound 193

Type

Small organic molecule

Emp. Form.

C27H31N5O4

Mol. Mass.

489.5661

SMILES

C[C@@H]1OC(=O)c2ccc(Nc3cc4c(cnc(O[C@H]5C[C@H](O)C5)c4cn3)[C@@](C)(N)C3CC3)nc2[C@H]1C |r,wU:26.29,18.17,34.40,wD:26.30,20.20,1.0,(8.16,8.71,;6.82,7.94,;6.82,6.4,;5.49,5.63,;5.49,4.09,;4.15,6.4,;2.82,5.63,;1.49,6.4,;1.49,7.94,;.15,8.71,;-1.18,7.94,;-2.51,8.71,;-3.85,7.94,;-5.18,8.71,;-6.51,7.94,;-6.51,6.4,;-5.18,5.63,;-5.18,4.09,;-3.85,3.32,;-2.36,3.72,;-1.96,2.23,;-.63,1.46,;-3.45,1.83,;-3.85,6.4,;-2.51,5.63,;-1.18,6.4,;-5.18,10.25,;-4.41,11.58,;-3.64,10.25,;-6.67,10.65,;-7.76,11.73,;-8.16,10.25,;2.82,8.71,;4.15,7.94,;5.49,8.71,;5.49,10.25,)|

Structure