| Reaction Details |
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 | Report a problem with these data |
| Target | Sigma non-opioid intracellular receptor 1 |
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| Ligand | BDBM587521 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Receptor Binding Assay |
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| Ki | 70.0±n/a nM |
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| Citation |  Smith, RA; Rideout, DC; Myers, KJ; Kawasaki, A Analogs of dextromethorphan with balanced receptor activities US Patent US11535596 Publication Date 12/27/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Sigma non-opioid intracellular receptor 1 |
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| Name: | Sigma non-opioid intracellular receptor 1 |
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| Synonyms: | Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 25124.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q99720 |
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| Residue: | 223 |
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| Sequence: | MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSR
LIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
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| BDBM587521 |
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| n/a |
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| Name | BDBM587521 |
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| Synonyms: | US11535596, Compound N-desmethyl CNS1-D2 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H23F2NO |
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| Mol. Mass. | 307.3781 |
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| SMILES | FC(F)COc1ccc2CC3NCCC4(CCCCC34)c2c1 |THB:21:20:19:11.13.12| |
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| Structure | 
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