| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Gamma-aminobutyric acid receptor subunit gamma-1 |
|---|
| Ligand | BDBM585946 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Steroid Inhibition of TBPS Binding |
|---|
| IC50 | <10±n/a nM |
|---|
| Citation |  Martinez Botella, G; Salituro, FG; Robichaud, AJ; Harrison, BL Compositions and methods for treating CNS disorders US Patent US11542297 Publication Date 1/3/2023 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Gamma-aminobutyric acid receptor subunit gamma-1 |
|---|
| Name: | Gamma-aminobutyric acid receptor subunit gamma-1 |
|---|
| Synonyms: | Benzodiazepine receptors | Benzodiazepine receptors; peripheral & central | GABA receptor gamma-1 subunit | GBRG1_RAT | Gabrg1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 53557.84 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_193817 |
|---|
| Residue: | 465 |
|---|
| Sequence: | MGSGKVFLFSPSLLWSQTRGVRLIFLLLTLHLGNCIDKADDEDDEDLTMNKTWVLAPKIH
EGDITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWF
DSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWSDGRVLYTL
RLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQFAF
VGLRNSTEISHTISGDYIIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVP
ARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYFTSN
NKGKTTRDRKLKSKTSVSPGLHAGSTLIPMNNISMPQGEDDYGYQCLEGKDCATFFCCFE
DCRTGSWREGRIHIRIAKIDSYSRIFFPTAFALFNLVYWVGYLYL
|
|
|
|---|
| BDBM585946 |
|---|
| n/a |
|---|
| Name | BDBM585946 |
|---|
| Synonyms: | US11530237, Compound 117 | US11542297, Compound 117 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H41N3O3 |
|---|
| Mol. Mass. | 479.6541 |
|---|
| SMILES | COc1cccc2nn(CC(=O)[C@H]3CC[C@H]4[C@@H]5CC[C@H]6C[C@](C)(O)CC[C@]6(C)[C@H]5CC[C@]34C)nc12 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
