| Reaction Details |
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 | Report a problem with these data |
| Target | Lysyl oxidase homolog 2 |
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| Ligand | BDBM469122 |
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| Substrate/Competitor | n/a |
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| IC50 | 72.0±n/a nM |
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| Citation |  Springer, C; Marais, R; Niculescu-Duvaz, D; Leung, L; Smithen, D; Callens, C; Tang, H Methylamine derivatives as lysysl oxidase inhibitors for the treatment of cancer US Patent US11608330 Publication Date 3/21/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysyl oxidase homolog 2 |
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| Name: | Lysyl oxidase homolog 2 |
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| Synonyms: | 1.4.3.13 | LOXL2 | LOXL2_HUMAN | Lysyl oxidase homolog 2 | Lysyl oxidase-like protein 2 | Lysyl oxidase-related protein 2 | Lysyl oxidase-related protein WS9-14 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 86721.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_115990 |
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| Residue: | 774 |
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| Sequence: | MERPLCSHLCSCLAMLALLSPLSLAQYDSWPHYPEYFQQPAPEYHQPQAPANVAKIQLRL
AGQKRKHSEGRVEVYYDGQWGTVCDDDFSIHAAHVVCRELGYVEAKSWTASSSYGKGEGP
IWLDNLHCTGNEATLAACTSNGWGVTDCKHTEDVGVVCSDKRIPGFKFDNSLINQIENLN
IQVEDIRIRAILSTYRKRTPVMEGYVEVKEGKTWKQICDKHWTAKNSRVVCGMFGFPGER
TYNTKVYKMFASRRKQRYWPFSMDCTGTEAHISSCKLGPQVSLDPMKNVTCENGLPAVVS
CVPGQVFSPDGPSRFRKAYKPEQPLVRLRGGAYIGEGRVEVLKNGEWGTVCDDKWDLVSA
SVVCRELGFGSAKEAVTGSRLGQGIGPIHLNEIQCTGNEKSIIDCKFNAESQGCNHEEDA
GVRCNTPAMGLQKKLRLNGGRNPYEGRVEVLVERNGSLVWGMVCGQNWGIVEAMVVCRQL
GLGFASNAFQETWYWHGDVNSNKVVMSGVKCSGTELSLAHCRHDGEDVACPQGGVQYGAG
VACSETAPDLVLNAEMVQQTTYLEDRPMFMLQCAMEENCLSASAAQTDPTTGYRRLLRFS
SQIHNNGQSDFRPKNGRHAWIWHDCHRHYHSMEVFTHYDLLNLNGTKVAEGHKASFCLED
TECEGDIQKNYECANFGDQGITMGCWDMYRHDIDCQWVDITDVPPGDYLFQVVINPNFEV
AESDYSNNIMKCRSRYDGHRIWMYNCHIGGSFSEETEKKFEHFSGLLNNQLSPQ
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| BDBM469122 |
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| n/a |
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| Name | BDBM469122 |
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| Synonyms: | (5-((3-Methoxy-5-(1-(methoxymethyl)-1H-pyrazol-4-yl)phenyl)sulfonyl)thiazol-2-yl)methanamine tri-trifluoroacetate and | US10807974, Example 141 | US10995088, Example 141 | US11608330, Example 141 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H18N4O4S2 |
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| Mol. Mass. | 394.469 |
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| SMILES | COCn1cc(cn1)-c1cc(OC)cc(c1)S(=O)(=O)c1cnc(CN)s1 |
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| Structure | 
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