| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histamine H3 receptor |
|---|
| Ligand | BDBM600479 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Determination of Ki Value at Human and Rat Histamin-3 Receptor |
|---|
| IC50 | 20.0±0 nM |
|---|
| Citation |  Nirogi, R; Shinde, AK; Benade, VS; Daripelli, S; Jayarajan, P; Ravula, J; Jasti, V Method of treatment with histamine-3 receptor inverse agonist US Patent US11622967 Publication Date 4/11/2023 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histamine H3 receptor |
|---|
| Name: | Histamine H3 receptor |
|---|
| Synonyms: | HH3R | HRH3_RAT | Hrh3 |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 48607.98 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | n/a |
|---|
| Residue: | 445 |
|---|
| Sequence: | MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCAS
SVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAG
PEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAA
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSL
AIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFR
RAFTKLLCPQKLKVQPHGSLEQCWK
|
|
|
|---|
| BDBM600479 |
|---|
| n/a |
|---|
| Name | BDBM600479 |
|---|
| Synonyms: | US11622967, Example SUVN-G3031 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H31N3O3 |
|---|
| Mol. Mass. | 373.4891 |
|---|
| SMILES | O=C(CN1CCOCC1)Nc1ccc(OC2CCN(CC2)C2CCC2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
