Reaction Details |
| Report a problem with these data |
Target | Isocitrate dehydrogenase [NADP], mitochondrial [R172K] |
---|
Ligand | BDBM497335 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Biochemical Assays for IDH1 and IDH2 Mutant Enzymes |
---|
IC50 | 11.5±n/a nM |
---|
Citation | Bauer, RA; Boulet, SL; Burkholder, TP; Gilmour, R; Hahn, PJ; Rankovic, Z 7-phenylethylamino-4H-pyrimido[4,5-d][1,3]oxazin-2-one compounds as mutant IDH1 and IDH2 inhibitors US Patent US11629156 Publication Date 4/18/2023 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Isocitrate dehydrogenase [NADP], mitochondrial [R172K] |
---|
Name: | Isocitrate dehydrogenase [NADP], mitochondrial [R172K] |
Synonyms: | IDH2 | IDHP_HUMAN | Isocitrate dehydrogenase [NADP], mitochondrial (IDH2)(R172K) |
Type: | n/a |
Mol. Mass.: | 50894.25 |
Organism: | Homo sapiens (Human) |
Description: | P48735[R172K] |
Residue: | 452 |
Sequence: | MAGYLRVVRSLCRASGSRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTR
IIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDE
ARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGQHAHGDQYK
ATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAI
QKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKS
SGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQK
GRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIH
GLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ
|
|
|
BDBM497335 |
---|
n/a |
---|
Name | BDBM497335 |
Synonyms: | 7-[[(1S)-1-[4-[(1S)-2- cyclopropyl-1-(4-prop-2- enoylpiperazin-1-yl) ethyl]phenyl]ethyl]amino]- 1-ethyl-4H-pyrimido[4,5- d][1,3]oxazin-2-one | US11001596, Example 2 | US11629156, Example 2 | US11649247, Example 2 |
Type | Small organic molecule |
Emp. Form. | C28H36N6O3 |
Mol. Mass. | 504.6238 |
SMILES | CCN1C(=O)OCc2cnc(N[C@@H](C)c3ccc(cc3)[C@H](CC3CC3)N3CCN(CC3)C(=O)C=C)nc12 |r| |
Structure |
|