Reaction Details |
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Target | Isocitrate dehydrogenase [NADP], mitochondrial [R140Q] |
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Ligand | BDBM600740 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Biochemical Assays for IDH1 and IDH2 Mutant Enzymes |
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IC50 | 74.3±n/a nM |
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Citation | Bauer, RA; Boulet, SL; Burkholder, TP; Gilmour, R; Hahn, PJ; Rankovic, Z 7-phenylethylamino-4H-pyrimido[4,5-d][1,3]oxazin-2-one compounds as mutant IDH1 and IDH2 inhibitors US Patent US11629156 Publication Date 4/18/2023 |
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More Info.: | Get all data from this article, Assay Method |
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Isocitrate dehydrogenase [NADP], mitochondrial [R140Q] |
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Name: | Isocitrate dehydrogenase [NADP], mitochondrial [R140Q] |
Synonyms: | IDH2 | IDHP_HUMAN | Isocitrate dehydrogenase 2 mutant (R140Q) |
Type: | Protein |
Mol. Mass.: | 50894.25 |
Organism: | Homo sapiens (Human) |
Description: | R140Q mutant |
Residue: | 452 |
Sequence: | MAGYLRVVRSLCRASGSRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTR
IIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDE
ARVEEFKLKKMWKSPNGTIQNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYK
ATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAI
QKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKS
SGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQK
GRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIH
GLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ
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BDBM600740 |
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n/a |
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Name | BDBM600740 |
Synonyms: | US11629156, Example 7 |
Type | n/a |
Emp. Form. | C28H38N6O3 |
Mol. Mass. | 506.6397 |
SMILES | CCN1C(=O)OCc2cnc(N[C@@H](C)c3ccc(cc3)[C@@H](CC(C)C)N3CCN(CC3)C(=O)C=C)nc12 |r| |
Structure |
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