| Reaction Details |
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 | Report a problem with these data |
| Target | Chitotriosidase-1 |
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| Ligand | BDBM601602 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | AMCase Activity Assay |
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| IC50 | <100±n/a nM |
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| Citation |  Mazur, M; Andryianau, G; Joachimiak, L; Czestkowski, W; Kowalski, M; Niedziejko, P; Olejniczak, S; Matyszewski, K; Koralewski, R; Olczak, J; Golebiowski, A; Bartoszewicz, A Substituted amino triazoles useful as chitinase inhibitors US Patent US11638707 Publication Date 5/2/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Chitotriosidase-1 |
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| Name: | Chitotriosidase-1 |
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| Synonyms: | CHIT1 | CHIT1_HUMAN | Chitinase 1 | Chitinase-1 | Chitotriosidase | Chitotriosidase-1 | Chitotriosidase-1 (CHIT1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 51682.25 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13231 |
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| Residue: | 466 |
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| Sequence: | MVRSVAWAGFMVLLMIPWGSAAKLVCYFTNWAQYRQGEARFLPKDLDPSLCTHLIYAFAG
MTNHQLSTTEWNDETLYQEFNGLKKMNPKLKTLLAIGGWNFGTQKFTDMVATANNRQTFV
NSAIRFLRKYSFDGLDLDWEYPGSQGSPAVDKERFTTLVQDLANAFQQEAQTSGKERLLL
SAAVPAGQTYVDAGYEVDKIAQNLDFVNLMAYDFHGSWEKVTGHNSPLYKRQEESGAAAS
LNVDAAVQQWLQKGTPASKLILGMPTYGRSFTLASSSDTRVGAPATGSGTPGPFTKEGGM
LAYYEVCSWKGATKQRIQDQKVPYIFRDNQWVGFDDVESFKTKVSYLKQKGLGGAMVWAL
DLDDFAGFSCNQGRYPLIQTLRQELSLPYLPSGTPELEVPKPGQPSEPEHGPSPGQDTFC
QGKADGLYPNPRERSSFYSCAAGRLFQQSCPTGLVFSNSCKCCTWN
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| BDBM601602 |
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| n/a |
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| Name | BDBM601602 |
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| Synonyms: | US11638707, Example 7. |
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| Type | Small organic molecule |
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| Emp. Form. | C23H32ClN7O2 |
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| Mol. Mass. | 473.999 |
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| SMILES | Nc1nnc([nH]1)N1CCC(CC1)N1C[C@H](CN2CCCC2=O)OC[C@@H]1Cc1ccc(Cl)cc1 |r| |
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| Structure | 
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