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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein phosphatase non-receptor type 11 | ||
| Ligand | BDBM503356 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | SHP2 Biochemical Assay | ||
| IC50 | 960±n/a nM | ||
| Citation |  Jorand-Lebrun, C; Boivin, R; Mochalkin, I; Johnson, T; Linde, N; Musch, D; Kumar, D Carboxamide-pyrimidine derivatives as SHP2 antagonists US Patent US11696916 Publication Date 7/11/2023 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein phosphatase non-receptor type 11 | |||
| Name: | Tyrosine-protein phosphatase non-receptor type 11 | ||
| Synonyms: | 3.1.3.48 | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2) | ||
| Type: | Protein phosphatase | ||
| Mol. Mass.: | 68443.59 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q06124 | ||
| Residue: | 593 | ||
| Sequence: |
| ||
| BDBM503356 | |||
| n/a | |||
| Name | BDBM503356 | ||
| Synonyms: | 5-(2,3-Dichloro-phenyl)-6-methyl-2- (5-methyl-hexahydro-pyrrolo[3,4- c]pyrrol-2-yl)-pyrimidine-4- carboxylic acid amide | US11033547, Compound 56 | US11696916, Compound 56 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H21Cl2N5O | ||
| Mol. Mass. | 406.309 | ||
| SMILES | CN1CC2CN(CC2C1)c1nc(C)c(-c2cccc(Cl)c2Cl)c(n1)C(N)=O |(7.76,.54,;6.22,.54,;5.31,-.7,;3.85,-.23,;2.39,-.7,;1.48,.54,;2.39,1.79,;3.85,1.31,;5.31,1.79,;-.06,.54,;-.83,1.88,;-2.37,1.88,;-3.14,3.21,;-3.14,.54,;-4.68,.54,;-5.45,-.79,;-6.99,-.79,;-7.76,.54,;-6.99,1.88,;-7.76,3.21,;-5.45,1.88,;-4.68,3.21,;-2.37,-.79,;-.83,-.79,;-3.14,-2.12,;-2.05,-3.21,;-4.68,-2.12,)| | ||
| Structure | 
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