Reaction Details | |||
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Target | Tyrosine-protein phosphatase non-receptor type 11 | ||
Ligand | BDBM503393 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | SHP2 Biochemical Assay | ||
IC50 | 62.0±n/a nM | ||
Citation | ![]() | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein phosphatase non-receptor type 11 | |||
Name: | Tyrosine-protein phosphatase non-receptor type 11 | ||
Synonyms: | 3.1.3.48 | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2) | ||
Type: | Protein phosphatase | ||
Mol. Mass.: | 68443.59 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q06124 | ||
Residue: | 593 | ||
Sequence: |
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BDBM503393 | |||
n/a | |||
Name | BDBM503393 | ||
Synonyms: | (5M)-2-[(1R)-1-amino-3,3-difluoro- 8-azaspiro[4.5]-decan-8-yl]-5-(2,3- dichloro-phenyl)-6- methylpyrimidine-4-carboxamide | US11033547, Compound 96 | US11033547, Compound 97 | US11696916, Compound 97 | ||
Type | Small organic molecule | ||
Emp. Form. | C21H23Cl2F2N5O | ||
Mol. Mass. | 470.343 | ||
SMILES | Cc1nc(nc(C(N)=O)c1-c1cccc(Cl)c1Cl)N1CCC2(CC(F)(F)C[C@H]2N)CC1 |r,wD:27.30,(-1.6,3.62,;-1.6,2.08,;-.27,1.31,;-.27,-.23,;-1.6,-1,;-2.94,-.23,;-4.27,-1,;-4.27,-2.54,;-5.6,-.23,;-2.94,1.31,;-4.27,2.08,;-5.6,1.31,;-6.94,2.08,;-6.94,3.62,;-5.6,4.39,;-5.6,5.93,;-4.27,3.62,;-2.94,4.39,;1.06,-1,;1.06,-2.54,;2.4,-3.31,;3.73,-2.54,;3.89,-4.07,;5.4,-4.39,;6.94,-4.39,;5.4,-5.93,;6.17,-3.06,;5.14,-1.91,;5.46,-.41,;3.73,-1,;2.4,-.23,)| | ||
Structure | ![]() |