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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein phosphatase non-receptor type 11 | ||
| Ligand | BDBM608516 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | SHP2 Biochemical Assay | ||
| IC50 | 2.00±n/a nM | ||
| Citation |  Jorand-Lebrun, C; Boivin, R; Mochalkin, I; Johnson, T; Linde, N; Musch, D; Kumar, D Carboxamide-pyrimidine derivatives as SHP2 antagonists US Patent US11696916 Publication Date 7/11/2023 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein phosphatase non-receptor type 11 | |||
| Name: | Tyrosine-protein phosphatase non-receptor type 11 | ||
| Synonyms: | 3.1.3.48 | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2) | ||
| Type: | Protein phosphatase | ||
| Mol. Mass.: | 68443.59 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q06124 | ||
| Residue: | 593 | ||
| Sequence: |
| ||
| BDBM608516 | |||
| n/a | |||
| Name | BDBM608516 | ||
| Synonyms: | 6-amino-2-[(4S)-4-amino-4,6- dihydrospiro[cyclopenta[d][1,3]thiazole- 5,4'-piperidin]-1'-yl]-5-(2,3- dichlorophenyl)pyrimidine-4- carboxamide | US11696916, Compound 121 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H22Cl2N6OS | ||
| Mol. Mass. | 489.421 | ||
| SMILES | Cc1nc(nc(C(N)=O)c1-c1cccc(Cl)c1Cl)N1CCC2(Cc3scnc3[C@H]2N)CC1 |r,wD:28.32,(-1.92,3.56,;-1.92,2.02,;-.58,1.25,;-.58,-.29,;-1.92,-1.06,;-3.25,-.29,;-4.58,-1.06,;-4.58,-2.6,;-5.92,-.29,;-3.25,1.25,;-4.58,2.02,;-5.92,1.25,;-7.25,2.02,;-7.25,3.56,;-5.92,4.33,;-5.92,5.87,;-4.58,3.56,;-3.25,4.33,;.75,-1.06,;.75,-2.6,;2.08,-3.37,;3.42,-2.6,;3.42,-4.14,;4.88,-4.62,;5.79,-5.87,;7.25,-5.39,;7.25,-3.85,;5.79,-3.37,;4.88,-2.13,;5.65,-.79,;3.42,-1.06,;2.08,-.29,)| | ||
| Structure | 
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