| Reaction Details |
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 | Report a problem with these data |
| Target | Plasma kallikrein |
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| Ligand | BDBM617970 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kallikrein Assay |
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| IC50 | 0.400±n/a nM |
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| Citation |  Jabri, S; Ogawa, AK; Sinz, CJ; Hicks, JD; Cheng, AC; Gao, Y; Yang, S; Bao, J; Hayes, DA; Lang, SB; Taoka, BM; Tian, M; Shearn-Nance, GP; Kuang, R; Lombardo, MJ; Wu, Z; Zhao, Z PLASMA KALLIKREIN INHIBITORS US Patent US20230286958 Publication Date 9/14/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Plasma kallikrein |
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| Name: | Plasma kallikrein |
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| Synonyms: | Fletcher factor | KLK3 | KLKB1 | KLKB1_HUMAN | Kallikrein | Kininogenin | Plasma kallikrein heavy chain | Plasma kallikrein light chain | Plasma prekallikrein |
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| Type: | Protein |
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| Mol. Mass.: | 71391.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03952 |
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| Residue: | 638 |
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| Sequence: | MILFKQATYFISLFATVSCGCLTQLYENAFFRGGDVASMYTPNAQYCQMRCTFHPRCLLF
SFLPASSINDMEKRFGCFLKDSVTGTLPKVHRTGAVSGHSLKQCGHQISACHRDIYKGVD
MRGVNFNVSKVSSVEECQKRCTSNIRCQFFSYATQTFHKAEYRNNCLLKYSPGGTPTAIK
VLSNVESGFSLKPCALSEIGCHMNIFQHLAFSDVDVARVLTPDAFVCRTICTYHPNCLFF
TFYTNVWKIESQRNVCLLKTSESGTPSSSTPQENTISGYSLLTCKRTLPEPCHSKIYPGV
DFGGEELNVTFVKGVNVCQETCTKMIRCQFFTYSLLPEDCKEEKCKCFLRLSMDGSPTRI
AYGTQGSSGYSLRLCNTGDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCG
GSLIGHQWVLTAAHCFDGLPLQDVWRIYSGILNLSDITKDTPFSQIKEIIIHQNYKVSEG
NHDIALIKLQAPLNYTEFQKPICLPSKGDTSTIYTNCWVTGWGFSKEKGEIQNILQKVNI
PLVTNEECQKRYQDYKITQRMVCAGYKEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGE
GCARREQPGVYTKVAEYMDWILEKTQSSDGKAQMQSPA
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| BDBM617970 |
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| n/a |
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| Name | BDBM617970 |
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| Synonyms: | 6-(3-Chloro-6-(difluoromethyl)-2-fluorophenyl)-3-(hydroxymethyl-d2)-N-(1-((S)-1-(2-((1R,5S)-2-oxo-3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-5-yl)ethyl)-1H-pyrazol-4-yl)pyrazine-2-carboxamide | US20230286958, Example 182 | US20230286958, Example 193 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H22ClF3N8O3 |
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| Mol. Mass. | 598.964 |
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| SMILES | C[C@@H](c1cnc(nc1)N1C[C@H]2C[C@H]2C1=O)n1cc(NC(=O)c2nc(cnc2CO)-c2c(F)c(Cl)ccc2C(F)F)cn1 |
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| Structure | 
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