Ki Summary

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Target

Furin [108-574]

Ligand

BDBM621464

Substrate/Competitor

n/a

Meas. Tech.

Furin Enzyme Assay

IC50

0.063±n/a nM

Citation

Axten, JM; Cheung, M; Demartino, MP; Guan, HA; Hu, Y; Miller, AB; Qin, D; Wu, C; Zhang, Z; Lin, X Furin inhibitors US Patent US11773078 Publication Date 10/3/2023

More Info.:

Get all data from this article, Assay Method

Furin [108-574]

Name:

Furin [108-574]

Synonyms:

Furin (108-574)

Type:

Enzyme Catalytic Domain

Mol. Mass.:

50656.86

Organism:

Homo sapiens (Human)

Description:

aa 108-574

Residue:

467

Sequence:

DVYQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNY
DPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRML
DGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGS
IFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQN
EKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLN
ANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEV
RKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADG
FNDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTA

BDBM621464

n/a

Name

BDBM621464

Synonyms:

US11773078, Example 216

Type

Small organic molecule

Emp. Form.

C33H39Cl2N7O4

Mol. Mass.

668.613

SMILES

CC(=O)NCC1CCN(Cc2cc(Oc3cnc(nc3)N3CCN(CC3)C3CC(C3)C(O)=O)nc(c2)-c2cc(Cl)cc(Cl)c2)CC1 |(14.28,-2.08,;12.95,-1.31,;12.95,.23,;11.61,-2.08,;10.28,-1.31,;8.94,-2.08,;8.94,-3.62,;7.61,-4.39,;6.28,-3.62,;4.94,-4.39,;3.61,-3.62,;2.28,-4.39,;.94,-3.62,;-.39,-4.39,;-1.72,-3.62,;-3.06,-4.39,;-4.39,-3.62,;-4.39,-2.08,;-3.06,-1.31,;-1.72,-2.08,;-5.73,-1.31,;-7.06,-2.08,;-8.39,-1.31,;-8.39,.23,;-7.06,1,;-5.73,.23,;-9.73,1,;-10.12,2.48,;-11.61,2.08,;-11.21,.6,;-12.95,2.85,;-14.28,2.08,;-12.95,4.39,;.94,-2.08,;2.28,-1.31,;3.61,-2.08,;2.28,.23,;.94,1,;.94,2.54,;-.39,3.31,;2.28,3.31,;3.61,2.54,;4.94,3.31,;3.61,1,;6.28,-2.08,;7.61,-1.31,)|

Structure