Ki Summary

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Target

Furin [108-574]

Ligand

BDBM621469

Substrate/Competitor

n/a

Meas. Tech.

Furin Enzyme Assay

IC50

0.040±n/a nM

Citation

Axten, JM; Cheung, M; Demartino, MP; Guan, HA; Hu, Y; Miller, AB; Qin, D; Wu, C; Zhang, Z; Lin, X Furin inhibitors US Patent US11773078 Publication Date 10/3/2023

More Info.:

Get all data from this article, Assay Method

Furin [108-574]

Name:

Furin [108-574]

Synonyms:

Furin (108-574)

Type:

Enzyme Catalytic Domain

Mol. Mass.:

50656.86

Organism:

Homo sapiens (Human)

Description:

aa 108-574

Residue:

467

Sequence:

DVYQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNY
DPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRML
DGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGS
IFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQN
EKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLN
ANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEV
RKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADG
FNDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTA

BDBM621469

n/a

Name

BDBM621469

Synonyms:

US11773078, Example 221

Type

Small organic molecule

Emp. Form.

C33H40Cl2N8O4

Mol. Mass.

683.628

SMILES

CNC(=O)NCC1CCN(Cc2cc(Oc3cnc(nc3)N3CCN(CC3)C3CC(C3)C(O)=O)nc(c2)-c2cc(Cl)cc(Cl)c2)CC1 |(14.95,-1.31,;13.61,-2.08,;12.28,-1.31,;12.28,.23,;10.95,-2.08,;9.61,-1.31,;8.28,-2.08,;8.28,-3.62,;6.94,-4.39,;5.61,-3.62,;4.28,-4.39,;2.94,-3.62,;1.61,-4.39,;.28,-3.62,;-1.06,-4.39,;-2.39,-3.62,;-3.72,-4.39,;-5.06,-3.62,;-5.06,-2.08,;-3.72,-1.31,;-2.39,-2.08,;-6.39,-1.31,;-7.73,-2.08,;-9.06,-1.31,;-9.06,.23,;-7.73,1,;-6.39,.23,;-10.39,1,;-10.79,2.48,;-12.28,2.08,;-11.88,.6,;-13.61,2.85,;-14.95,2.08,;-13.61,4.39,;.28,-2.08,;1.61,-1.31,;2.94,-2.08,;1.61,.23,;.28,1,;.28,2.54,;-1.06,3.31,;1.61,3.31,;2.94,2.54,;4.28,3.31,;2.94,1,;5.61,-2.08,;6.94,-1.31,)|

Structure