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TargetFurin [108-574]
LigandBDBM621615
Substrate/Competitorn/a
Meas. Tech.Furin Enzyme Assay
IC50 0.079±n/a nM
Citation Axten, JMCheung, MDemartino, MPGuan, HAHu, YMiller, ABQin, DWu, CZhang, ZLin, X Furin inhibitors US Patent US11773078 Publication Date 10/3/2023
More Info.:Get all data from this article,  Assay Method
 
Furin [108-574]
Name:Furin [108-574]
Synonyms:Furin (108-574)
Type:Enzyme Catalytic Domain
Mol. Mass.:50656.86
Organism:Homo sapiens (Human)
Description:aa 108-574
Residue:467
Sequence:
DVYQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNY
DPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRML
DGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGS
IFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQN
EKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLN
ANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEV
RKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADG
FNDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM621615
n/a
NameBDBM621615
Synonyms:US11773078, Example 367
TypeSmall organic molecule
Emp. Form.C32H37Cl2N7O4
Mol. Mass.654.587
SMILESCC(=O)N[C@@H]1[C@H]2CCN(Cc3cc(Oc4cnc(nc4)N4CCN(CCC(O)=O)CC4)nc(c3)-c3cc(Cl)cc(Cl)c3)CC[C@@H]12 |r|
Structure
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