| Reaction Details |
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 | Report a problem with these data |
| Target | Fibroblast growth factor receptor 2 |
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| Ligand | BDBM50604027 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinase (PDGFRα, PDGFRβ, ABL1 and FLT3) Inhibition Test of Compounds |
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| IC50 | 27.0±n/a nM |
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| Citation |  LI, X; LIU, Z; LIN, L; ZHENG, X; QIAN, J PYRIMIDINE SMALL-MOLECULE COMPOUND AND APPLICATION THEREOF US Patent US20230312529 Publication Date 10/5/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Fibroblast growth factor receptor 2 |
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| Name: | Fibroblast growth factor receptor 2 |
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| Synonyms: | BEK | CD_antigen=CD332 | FGFR-2 | FGFR-2 Tyrosine Kinase | FGFR2 | FGFR2_HUMAN | Fibroblast growth factor receptor 2 (FGFR2) | Fibroblast growth factor receptor 2 precursor | KGFR | KSAM | Keratinocyte growth factor receptor | Keratinocyte growth factor receptor 2 | VEGF-receptor 2 and Fibroblast growth factor receptor 2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 92015.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21802 |
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| Residue: | 821 |
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| Sequence: | MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV
RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF
MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI
NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK
YGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL
PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTK
RIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDK
LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM
IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTF
KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT
TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH
RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYS
PSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
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| BDBM50604027 |
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| n/a |
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| Name | BDBM50604027 |
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| Synonyms: | CHEMBL5184634 | US20230312529, Compound 6i |
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| Type | Small organic molecule |
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| Emp. Form. | C25H30N8O |
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| Mol. Mass. | 458.5587 |
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| SMILES | CCN1CCN(CC1)c1ccc(Nc2ncc(C)c(Nc3ccc4cn[nH]c4c3)n2)cc1OC |
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| Structure | 
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