| Reaction Details |
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 | Report a problem with these data |
| Target | Protein kinase C beta type Isoform 2 |
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| Ligand | BDBM286241 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Protein Kinase C beta 2 (PKCpII) Assay |
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| Ki | 10.8±n/a nM |
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| Citation |  Li, H; Nukui, S; Scales, SA; Teng, M; Yin, C Substituted N-pyrimidin-4-yl-3-aminopyrrolo[3,4-C]pyrazoles as protein kinase C inhibitors US Patent US11780853 Publication Date 10/10/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein kinase C beta type Isoform 2 |
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| Name: | Isoform Beta-II of Protein kinase C beta type (PRKCB2) |
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| Synonyms: | KPCB_HUMAN | PKCB | PRKCB | PRKCB1 | Protein kinase C beta II type | Protein kinase C beta type (PRKCB2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 77017.33 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P05771-2 |
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| Residue: | 673 |
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| Sequence: | MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGF
GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGS
LLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDA
KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRL
SVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPVPPEGSEANEE
LRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSE
RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVM
EYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHI
KIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAP
FEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF
RYIDWEKLERKEIQPPYKPKACGRNAENFDRFFTRHPPVLTPPDQEVIRNIDQSEFEGFS
FVNSEFLKPEVKS
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| BDBM286241 |
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| n/a |
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| Name | BDBM286241 |
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| Synonyms: | US11220518, Ex. No. A6 | US11780853, Example A6 | US9518060, Example A6 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H32FN9O |
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| Mol. Mass. | 445.5369 |
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| SMILES | CNc1ncc(F)c(Nc2n[nH]c3c2CN(C(=O)N2CC(C)(C)N(C)C[C@@H]2C)C3(C)C)n1 |r| |
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| Structure | 
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