Ki Summary

Reaction Details

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Target

Protein kinase C beta type Isoform 2

Ligand

BDBM286246

Substrate/Competitor

n/a

Meas. Tech.

Protein Kinase C beta 2 (PKCpII) Assay

1.01±n/a nM

Citation

Li, H; Nukui, S; Scales, SA; Teng, M; Yin, C Substituted N-pyrimidin-4-yl-3-aminopyrrolo[3,4-C]pyrazoles as protein kinase C inhibitors US Patent US11780853 Publication Date 10/10/2023

More Info.:

Get all data from this article, Assay Method

Protein kinase C beta type Isoform 2

Name:

Isoform Beta-II of Protein kinase C beta type (PRKCB2)

Synonyms:

Type:

Enzyme

Mol. Mass.:

77017.33

Organism:

Homo sapiens (Human)

Description:

P05771-2

Residue:

673

Sequence:

MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGF
GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGS
LLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDA
KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRL
SVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPVPPEGSEANEE
LRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSE
RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVM
EYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHI
KIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAP
FEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF
RYIDWEKLERKEIQPPYKPKACGRNAENFDRFFTRHPPVLTPPDQEVIRNIDQSEFEGFS
FVNSEFLKPEVKS

BDBM286246

n/a

Name

BDBM286246

Synonyms:

5-{[(8S)-6,8-dimethyl-6,9-diazaspiro[4.5]dec-9-yl]carbonyl}-N-(5-fluoro-2-methylpyrimidin-4-yl)-6,6-dimethyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-amine | US11220518, Ex. No. A10 | US11780853, Example A10 | US9518060, Example A10

Type

Small organic molecule

Emp. Form.

C23H33FN8O

Mol. Mass.

456.5595

SMILES

C[C@H]1CN(C)C2(CCCC2)CN1C(=O)N1Cc2c(Nc3nc(C)ncc3F)n[nH]c2C1(C)C |r|

Structure