Reaction Details |
| Report a problem with these data |
Target | Poly [ADP-ribose] polymerase 2 |
---|
Ligand | BDBM628460 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Biochemical (FP) Assay |
---|
IC50 | >100000±n/a nM |
---|
Citation | Hoffman, RL; Va, PJ; Pinchman, JR; Dong, Q; Kaldor, SW Substituted pyridines as PARP1 inhibitors US Patent US11795173 Publication Date 10/24/2023 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Poly [ADP-ribose] polymerase 2 |
---|
Name: | Poly [ADP-ribose] polymerase 2 |
Synonyms: | (ARTD2 or PARP2) | ADPRT2 | ADPRTL2 | PARP2 | PARP2_HUMAN | Poly [ADP-ribose] polymerase 2 (PARP-2) | Poly [ADP-ribose] polymerase 2 (PARP2) |
Type: | Enzyme |
Mol. Mass.: | 66225.70 |
Organism: | Homo sapiens (Human) |
Description: | Q9UGN5 |
Residue: | 583 |
Sequence: | MAARRRRSTGGGRARALNESKRVNNGNTAPEDSSPAKKTRRCQRQESKKMPVAGGKANKD
RTEDKQDGMPGRSWASKRVSESVKALLLKGKAPVDPECTAKVGKAHVYCEGNDVYDVMLN
QTNLQFNNNKYYLIQLLEDDAQRNFSVWMRWGRVGKMGQHSLVACSGNLNKAKEIFQKKF
LDKTKNNWEDREKFEKVPGKYDMLQMDYATNTQDEEETKKEESLKSPLKPESQLDLRVQE
LIKLICNVQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALME
ACNEFYTRIPHDFGLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKTELQSPEHPLDQ
HYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDL
HNRMLLWHGSRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLK
NTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGP
ASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLKVQFNFLQLW
|
|
|
BDBM628460 |
---|
n/a |
---|
Name | BDBM628460 |
Synonyms: | US11795173, Example 28 | US11795173, Example 33 | US11795173, Example 34 |
Type | Small organic molecule |
Emp. Form. | C22H20F3N7O2 |
Mol. Mass. | 471.4351 |
SMILES | CNC(=O)c1ccc(N2CCN(Cc3ccc4c([nH]c(=O)c5c(F)cnn45)c3F)CC2)c(F)n1 |
Structure |
|