Reaction Details |
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Target | Alpha-1-antitrypsin |
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Ligand | BDBM629228 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Biochemical Assay (Z-AAT Elastase Activity Assay) |
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IC50 | <2000±n/a nM |
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Citation | GIROUX, S; CLARK, MP; TANG, Q; NUHANT, PM; JONES, P; MESSERSMITH, D; BANDARAGE, UK; COTTRELL, KM; BRODNEY, MA; FLEMING, GS; WANG, J; XU, J; DANIEL, KB; BOYD, MJ; MORRIS, MA; WAAL, ND; COLLIER, PN; KESAVAN, S; RONKIN, SM; DENG, H; BOUCHER, DM; FANNING, LT; HALL, AB; HURLEY, DJ; JOHNSON, Jr., MA; MAXWELL, JP; SWETT, RJ; TAPLEY, TL; THOMSON, SA; DAMAGNEZ, V MODULATORS OF ALPHA-1 ANTITRYPSIN US Patent US20230339915 Publication Date 10/26/2023 |
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More Info.: | Get all data from this article, Assay Method |
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Alpha-1-antitrypsin |
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Name: | Alpha-1-antitrypsin |
Synonyms: | Alpha-1 protease inhibitor | Alpha-1-antiproteinase | Serpin A1 |
Type: | Protein |
Mol. Mass.: | 46727.42 |
Organism: | Human |
Description: | P01009 |
Residue: | 418 |
Sequence: | MPSSVSWGILLLAGLCCLVPVSLAEDPQGDAAQKTDTSHHDQDHPTFNKITPNLAEFAFS
LYRQLAHQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGF
QELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQ
INDYVEKGTQGKIVDLVKELDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTV
KVPMMKRLGMFNIQHCKKLSSWVLLMKYLGNATAIFFLPDEGKLQHLENELTHDIITKFL
ENEDRRSASLHLPKLSITGTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKA
VLTIDEKGTEAAGAMFLEAIPMSIPPEVKFNKPFVFLMIEQNTKSPLFMGKVVNPTQK
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BDBM629228 |
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n/a |
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Name | BDBM629228 |
Synonyms: | Synthesis of 4-(4-chloro-1-(4-fluorophenyl)-5-hydroxy-2-(I-methoxy-2-methylpropan-2-yl)-1H-indol-3-yl)benzoic acid (178) | US20230339915, Compound 178 |
Type | Small organic molecule |
Emp. Form. | C26H23ClFNO4 |
Mol. Mass. | 467.917 |
SMILES | COCC(C)(C)c1c(-c2ccc(cc2)C(O)=O)c2c(Cl)c(O)ccc2n1-c1ccc(F)cc1 |
Structure |
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