Reaction Details |
| Report a problem with these data |
Target | Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C] |
---|
Ligand | BDBM631490 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | SOS1 KRas(G12C) FRET Assay |
---|
IC50 | 4.60±n/a nM |
---|
Citation | Levinson, AM; Houang, E; Leffler, AE; Placzek, A; Ruvinsky, A; Greenwood, JR; Konst, Z; Frye, L HETEROCYCLIC COMPOUNDS AND METHODS OF USE US Patent US20230348424 Publication Date 11/2/2023 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C] |
---|
Name: | Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C] |
Synonyms: | SOS1 KRas(G12C) |
Type: | Protein |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Son of sevenless homolog 1 [564-1049] |
Synonyms: | SOS1 | SOS1_HUMAN | Son of sevenless homolog 1 (SOS1)(564-1049) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 56970.22 |
Organism: | n/a |
Description: | aa 564-1049 |
Residue: | 486 |
Sequence: | EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNF
VRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQ
PVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIA
RDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSE
LVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQ
ELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSIN
PPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRV
ESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPS
NPRPGT
|
|
|
Component 2 |
Name: | GTPase KRas [G12C] |
Synonyms: | GTPase KRas (G12C) | KRAS | KRAS2 | RASK2 | RASK_HUMAN |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 21702.19 |
Organism: | Homo sapiens (Human) |
Description: | P01116[G12C] |
Residue: | 189 |
Sequence: | MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC
VKIKKCIIM
|
|
|
BDBM631490 |
---|
n/a |
---|
Name | BDBM631490 |
Synonyms: | 1-((1R,2S)-[1,1′-bi(cyclopropan)]-2-yl)-N-((R)-1-(3- (difluoromethyl)-2-fluorophenyl)ethyl)-4-((1-methylpiperidin-4-yl)amino)-6-oxo-1,6- dihydropyridine-3-carboxamide | US20230348424, Example 73 | US20230348424, Example 74 |
Type | Small organic molecule |
Emp. Form. | C27H33F3N4O2 |
Mol. Mass. | 502.5717 |
SMILES | C[C@@H](NC(=O)c1cn([C@H]2C[C@@H]2C2CC2)c(=O)cc1NC1CCN(C)CC1)c1cccc(C(F)F)c1F |
Structure |
|