| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Lysyl oxidase homolog 2 |
|---|
| Ligand | BDBM633180 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Inhibition of LOX and LOXL1-4 |
|---|
| IC50 | <300±n/a nM |
|---|
| Citation |  Findlay, AD; Turner, CI; Deodhar, M; Foot, JS; Jarolimek, W; Schilter Sambade, H; Zhou, W; Perryman, LA BIOPROBES FOR LYSYL OXIDASES AND USES THEREOF US Patent US20230349907 Publication Date 11/2/2023 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Lysyl oxidase homolog 2 |
|---|
| Name: | Lysyl oxidase homolog 2 |
|---|
| Synonyms: | 1.4.3.13 | LOXL2 | LOXL2_HUMAN | Lysyl oxidase homolog 2 | Lysyl oxidase-like protein 2 | Lysyl oxidase-related protein 2 | Lysyl oxidase-related protein WS9-14 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 86721.38 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_115990 |
|---|
| Residue: | 774 |
|---|
| Sequence: | MERPLCSHLCSCLAMLALLSPLSLAQYDSWPHYPEYFQQPAPEYHQPQAPANVAKIQLRL
AGQKRKHSEGRVEVYYDGQWGTVCDDDFSIHAAHVVCRELGYVEAKSWTASSSYGKGEGP
IWLDNLHCTGNEATLAACTSNGWGVTDCKHTEDVGVVCSDKRIPGFKFDNSLINQIENLN
IQVEDIRIRAILSTYRKRTPVMEGYVEVKEGKTWKQICDKHWTAKNSRVVCGMFGFPGER
TYNTKVYKMFASRRKQRYWPFSMDCTGTEAHISSCKLGPQVSLDPMKNVTCENGLPAVVS
CVPGQVFSPDGPSRFRKAYKPEQPLVRLRGGAYIGEGRVEVLKNGEWGTVCDDKWDLVSA
SVVCRELGFGSAKEAVTGSRLGQGIGPIHLNEIQCTGNEKSIIDCKFNAESQGCNHEEDA
GVRCNTPAMGLQKKLRLNGGRNPYEGRVEVLVERNGSLVWGMVCGQNWGIVEAMVVCRQL
GLGFASNAFQETWYWHGDVNSNKVVMSGVKCSGTELSLAHCRHDGEDVACPQGGVQYGAG
VACSETAPDLVLNAEMVQQTTYLEDRPMFMLQCAMEENCLSASAAQTDPTTGYRRLLRFS
SQIHNNGQSDFRPKNGRHAWIWHDCHRHYHSMEVFTHYDLLNLNGTKVAEGHKASFCLED
TECEGDIQKNYECANFGDQGITMGCWDMYRHDIDCQWVDITDVPPGDYLFQVVINPNFEV
AESDYSNNIMKCRSRYDGHRIWMYNCHIGGSFSEETEKKFEHFSGLLNNQLSPQ
|
|
|
|---|
| BDBM633180 |
|---|
| n/a |
|---|
| Name | BDBM633180 |
|---|
| Synonyms: | 4-((1-((Z)-4-amino-2-fluorobut-2-en-1-yl)-2-methyl-5-(4-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoyl)piperazine-1-carbonyl)-1H-indol-3-yl)methyl)-N,N-dimethylbenzenesulfonamide hydrochloride | US20230349907, Compound 1-1 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C37H48FN7O5S2 |
|---|
| Mol. Mass. | 753.949 |
|---|
| SMILES | CN(C)S(=O)(=O)c1ccc(Cc2c(C)n(C\C(F)=C\CN)c3ccc(cc23)C(=O)N2CCN(CC2)C(=O)CCCC[C@@H]2SC[C@@H]3NC(=O)N[C@H]23)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
