| Reaction Details |
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 | Report a problem with these data |
| Target | Lysyl oxidase homolog 4 |
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| Ligand | BDBM633246 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition of LOX and LOXL1-4 |
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| IC50 | <300±n/a nM |
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| Citation |  Findlay, AD; Turner, CI; Deodhar, M; Foot, JS; Jarolimek, W; Schilter Sambade, H; Zhou, W; Perryman, LA BIOPROBES FOR LYSYL OXIDASES AND USES THEREOF US Patent US20230349907 Publication Date 11/2/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysyl oxidase homolog 4 |
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| Name: | Lysyl oxidase homolog 4 |
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| Synonyms: | 1.4.3.- | LOXC | LOXL4 | LOXL4_HUMAN | Lysyl oxidase homolog 4 | Lysyl oxidase-like protein 4 | Lysyl oxidase-related protein C |
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| Type: | PROTEIN |
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| Mol. Mass.: | 84498.74 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_118171 |
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| Residue: | 756 |
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| Sequence: | MAWSPPATLFLFLLLLGQPPPSRPQSLGTTKLRLVGPESKPEEGRLEVLHQGQWGTVCDD
NFAIQEATVACRQLGFEAALTWAHSAKYGQGEGPIWLDNVRCVGTESSLDQCGSNGWGVS
DCSHSEDVGVICHPRRHRGYLSETVSNALGPQGRRLEEVRLKPILASAKQHSPVTEGAVE
VKYEGHWRQVCDQGWTMNNSRVVCGMLGFPSEVPVDSHYYRKVWDLKMRDPKSRLKSLTN
KNSFWIHQVTCLGTEPHMANCQVQVAPARGKLRPACPGGMHAVVSCVAGPHFRPPKTKPQ
RKGSWAEEPRVRLRSGAQVGEGRVEVLMNRQWGTVCDHRWNLISASVVCRQLGFGSAREA
LFGARLGQGLGPIHLSEVRCRGYERTLSDCPALEGSQNGCQHENDAAVRCNVPNMGFQNQ
VRLAGGRIPEEGLLEVQVEVNGVPRWGSVCSENWGLTEAMVACRQLGLGFAIHAYKETWF
WSGTPRAQEVVMSGVRCSGTELALQQCQRHGPVHCSHGGGRFLAGVSCMDSAPDLVMNAQ
LVQETAYLEDRPLSQLYCAHEENCLSKSADHMDWPYGYRRLLRFSTQIYNLGRTDFRPKT
GRDSWVWHQCHRHYHSIEVFTHYDLLTLNGSKVAEGHKASFCLEDTNCPTGLQRRYACAN
FGEQGVTVGCWDTYRHDIDCQWVDITDVGPGNYIFQVIVNPHYEVAESDFSNNMLQCRCK
YDGHRVWLHNCHTGNSYPANAELSLEQEQRLRNNLI
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| BDBM633246 |
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| n/a |
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| Name | BDBM633246 |
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| Synonyms: | (3aS,3a'S,4S,4'S,6aR,6a′R)-4,4′-(((((5-(1-(3-(((Z)-4-amino-2-fluorobut-2-en-1-yl)sulfonyl)benzil)-1H-1,2,3-triazol-4-yl)-1,3-phenylene)bis(oxy))bis(propane-3,1-diyl))bis(1H-1,2,3-triazole-4,1-diyl))bis(pentane-5,1-diyl))bis(tetrahydro-1H-thieno[3,4-d]imidazol-2(3H)-one) hydrochloride | US20230349907, Compound 1-12 |
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| Type | Small organic molecule |
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| Emp. Form. | C49H65FN14O6S3 |
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| Mol. Mass. | 1061.324 |
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| SMILES | NC\C=C(/F)CS(=O)(=O)c1cccc(Cn2cc(nn2)-c2cc(OCCCc3cn(CCCCC[C@@H]4SC[C@@H]5NC(=O)N[C@H]45)nn3)cc(OCCCc3cn(CCCCC[C@@H]4SC[C@@H]5NC(=O)N[C@H]45)nn3)c2)c1 |r| |
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| Structure | 
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