| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein-lysine 6-oxidase |
|---|
| Ligand | BDBM633248 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Inhibition of LOX and LOXL1-4 |
|---|
| IC50 | >300±n/a nM |
|---|
| Citation |  Findlay, AD; Turner, CI; Deodhar, M; Foot, JS; Jarolimek, W; Schilter Sambade, H; Zhou, W; Perryman, LA BIOPROBES FOR LYSYL OXIDASES AND USES THEREOF US Patent US20230349907 Publication Date 11/2/2023 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Protein-lysine 6-oxidase |
|---|
| Name: | Protein-lysine 6-oxidase |
|---|
| Synonyms: | 1.4.3.13 | LOX | LYOX_BOVIN | Lysyl oxidase | Protein-lysine 6-oxidase | Protein-lysine 6-oxidase, long form | Protein-lysine 6-oxidase, short form |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 47015.72 |
|---|
| Organism: | Bos taurus |
|---|
| Description: | ChEMBL_118967 |
|---|
| Residue: | 417 |
|---|
| Sequence: | MRFAWTALLGSLQLCALVRCAPPAASHRQPPREQAAAPGAWRQKIQWENNGQVFSLLSLG
SQYQPQRRRDPGATAPGAANATAPQMRTPILLLRNNRTAAARVRTAGPSAAAAGRPRPAA
RHWFQAGYSTSGAHDAGTSRADNQTAPGEVPTLSNLRPPNRVEVDGMVGDDPYNPYKYTD
DNPYYNYYDTYERPRPGSRYRPGYGTGYFQYGLPDLVPDPYYIQASTYVQKMAMYNLRCA
AEENCLASSAYRDVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDE
FSHYDLLDASTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYNADID
CQWIDITDVKPGNYILKVSVNPSYLVPESDYSNNVVRCEIRYTGHHAYASGCTISPY
|
|
|
|---|
| BDBM633248 |
|---|
| n/a |
|---|
| Name | BDBM633248 |
|---|
| Synonyms: | (3aS,4S,6aR)-4-(4-(4-(3-((3-(((Z)-4-amino-2-fluorobut-2-en-1-yl)sulfonyl)phenyl)amino)propyl)-1H-1,2,3-triazol-1-yl)butyl)tetrahydro-1H-thieno[3,4-d]imidazol-2(3H)-one hydrochloride | US20230349907, Compound 1-14 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H36FN7O3S2 |
|---|
| Mol. Mass. | 565.727 |
|---|
| SMILES | NC\C=C(/F)CS(=O)(=O)c1cccc(NCCCc2cn(CCCCC[C@@H]3SC[C@@H]4NC(=O)N[C@H]34)nn2)c1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
