Ki Summary

Reaction Details

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Target

Interleukin-1 receptor-associated kinase 4

Ligand

BDBM639199

Substrate/Competitor

n/a

Meas. Tech.

IRAK4 ADP-Glo Assay

IC50

5.60±n/a nM

Citation

Chen, Y; Masuda, E; Lamagna, C BICYCLIC INHIBITORS OF IRAK US Patent US20230391748 Publication Date 12/7/2023

More Info.:

Get all data from this article, Assay Method

Interleukin-1 receptor-associated kinase 4

Name:

Interleukin-1 receptor-associated kinase 4

Synonyms:

Type:

Protein

Mol. Mass.:

51519.08

Organism:

Homo sapiens (Human)

Description:

Q9NWZ3

Residue:

460

Sequence:

MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS

BDBM639199

n/a

Name

BDBM639199

Synonyms:

4-((cis-4-ethoxycyclohexyl)ethynyl)-7-isopropoxy-1-(((S)-5-oxopyrrolidin-2-yl)methoxy)isoquinoline-6-carboxamide | US20230391748, Compound I-21

Type

Small organic molecule

Emp. Form.

C28H35N3O5

Mol. Mass.

493.5946

SMILES

CCO[C@H]1CC[C@H](CC1)C#Cc1cnc(OC[C@@H]2CCC(=O)N2)c2cc(OC(C)C)c(cc12)C(N)=O |r,wU:17.17,6.9,3.2,(-11.09,-.71,;-9.55,-.71,;-8.78,-2.04,;-7.24,-2.04,;-6.47,-.71,;-4.93,-.71,;-4.16,-2.04,;-4.93,-3.38,;-6.47,-3.38,;-2.62,-2.04,;-1.08,-2.04,;.46,-2.04,;1.23,-3.38,;2.77,-3.38,;3.54,-2.04,;5.08,-2.04,;5.85,-3.38,;7.39,-3.38,;8.29,-4.62,;9.76,-4.15,;9.76,-2.61,;11.09,-1.84,;8.29,-2.13,;2.77,-.71,;3.54,.62,;2.77,1.96,;3.54,3.29,;5.08,3.29,;5.85,4.62,;5.85,1.96,;1.23,1.96,;.46,.62,;1.23,-.71,;.46,3.29,;1.23,4.62,;-1.08,3.29,)|

Structure