| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Interleukin-1 receptor-associated kinase 4 |
|---|
| Ligand | BDBM639207 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | IRAK4 ADP-Glo Assay |
|---|
| IC50 | 5.50±n/a nM |
|---|
| Citation |  Chen, Y; Masuda, E; Lamagna, C BICYCLIC INHIBITORS OF IRAK US Patent US20230391748 Publication Date 12/7/2023 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Interleukin-1 receptor-associated kinase 4 |
|---|
| Name: | Interleukin-1 receptor-associated kinase 4 |
|---|
| Synonyms: | IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 51519.08 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9NWZ3 |
|---|
| Residue: | 460 |
|---|
| Sequence: | MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
|
|
|
|---|
| BDBM639207 |
|---|
| n/a |
|---|
| Name | BDBM639207 |
|---|
| Synonyms: | (S)-7-isopropoxy-4-((1-(methylcarbamoyl)azetidin-3-yl)ethynyl)-1-((5-oxopyrrolidin-2-yl)methoxy)isoquinoline-6-carboxamide | US20230391748, Compound I-29 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H29N5O5 |
|---|
| Mol. Mass. | 479.5283 |
|---|
| SMILES | CNC(=O)N1CC(C1)C#Cc1cnc(OC[C@@H]2CCC(=O)N2)c2cc(OC(C)C)c(cc12)C(N)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
