Ki Summary

Reaction Details

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Target

Interleukin-1 receptor-associated kinase 4

Ligand

BDBM639209

Substrate/Competitor

n/a

Meas. Tech.

IRAK4 ADP-Glo Assay

IC50

3.50±n/a nM

Citation

Chen, Y; Masuda, E; Lamagna, C BICYCLIC INHIBITORS OF IRAK US Patent US20230391748 Publication Date 12/7/2023

More Info.:

Get all data from this article, Assay Method

Interleukin-1 receptor-associated kinase 4

Name:

Interleukin-1 receptor-associated kinase 4

Synonyms:

Type:

Protein

Mol. Mass.:

51519.08

Organism:

Homo sapiens (Human)

Description:

Q9NWZ3

Residue:

460

Sequence:

MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS

BDBM639209

n/a

Name

BDBM639209

Synonyms:

4-((cis-3-(dimethylamino)cyclobutyl)ethynyl)-7-isopropoxy-1-(((S)-5-oxopyrrolidin-2-yl)methoxy)isoquinoline-6-carboxamide | US20230391748, Compound I-31

Type

Small organic molecule

Emp. Form.

C26H32N4O4

Mol. Mass.

464.5567

SMILES

CC(C)Oc1cc2c(OC[C@@H]3CCC(=O)N3)ncc(C#C[C@H]3C[C@H](C3)N(C)C)c2cc1C(N)=O |r,wU:10.9,21.21,23.26,(4.63,4.62,;3.86,3.29,;4.63,1.96,;2.32,3.29,;1.55,1.96,;2.32,.62,;1.55,-.71,;2.32,-2.04,;3.86,-2.04,;4.63,-3.38,;6.17,-3.38,;7.07,-4.62,;8.54,-4.15,;8.54,-2.61,;9.87,-1.84,;7.07,-2.13,;1.55,-3.38,;.01,-3.38,;-.76,-2.04,;-2.3,-2.04,;-3.84,-2.04,;-5.38,-2.04,;-6.47,-3.13,;-7.56,-2.04,;-6.47,-.96,;-9.1,-2.04,;-9.87,-3.38,;-9.87,-.71,;.01,-.71,;-.76,.62,;.01,1.96,;-.76,3.29,;.01,4.62,;-2.3,3.29,)|

Structure