Ki Summary

Reaction Details

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Target

Interleukin-1 receptor-associated kinase 4

Ligand

BDBM639237

Substrate/Competitor

n/a

Meas. Tech.

IRAK4 ADP-Glo Assay

IC50

3.90±n/a nM

Citation

Chen, Y; Masuda, E; Lamagna, C BICYCLIC INHIBITORS OF IRAK US Patent US20230391748 Publication Date 12/7/2023

More Info.:

Get all data from this article, Assay Method

Interleukin-1 receptor-associated kinase 4

Name:

Interleukin-1 receptor-associated kinase 4

Synonyms:

Type:

Protein

Mol. Mass.:

51519.08

Organism:

Homo sapiens (Human)

Description:

Q9NWZ3

Residue:

460

Sequence:

MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS

BDBM639237

n/a

Name

BDBM639237

Synonyms:

1-(((S)-4,4-difluoro-5-oxopyrrolidin-2-yl)methoxy)-4-((cis-4-ethoxycyclohexyl)ethynyl)-7-isopropoxyisoquinoline-6-carboxamide | US20230391748, Compound I-59

Type

Small organic molecule

Emp. Form.

C28H33F2N3O5

Mol. Mass.

529.5755

SMILES

CCO[C@H]1CC[C@H](CC1)C#Cc1cnc(OC[C@@H]2CC(F)(F)C(=O)N2)c2cc(OC(C)C)c(cc12)C(N)=O |r,wU:17.17,6.9,3.2,(-11.17,-.28,;-9.63,-.28,;-8.86,-1.62,;-7.32,-1.62,;-6.55,-.28,;-5.01,-.28,;-4.24,-1.62,;-5.01,-2.95,;-6.55,-2.95,;-2.7,-1.62,;-1.16,-1.62,;.38,-1.62,;1.15,-2.95,;2.69,-2.95,;3.46,-1.62,;5,-1.62,;5.77,-2.95,;7.31,-2.95,;8.22,-4.2,;9.68,-3.72,;11.17,-4.12,;10.45,-5.05,;9.68,-2.18,;11.02,-1.41,;8.22,-1.7,;2.69,-.28,;3.46,1.05,;2.69,2.39,;3.46,3.72,;5,3.72,;5.77,5.05,;5.77,2.39,;1.15,2.39,;.38,1.05,;1.15,-.28,;.38,3.72,;1.15,5.05,;-1.16,3.72,)|

Structure