Ki Summary

Reaction Details

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Target

Interleukin-1 receptor-associated kinase 4

Ligand

BDBM639251

Substrate/Competitor

n/a

Meas. Tech.

IRAK4 ADP-Glo Assay

IC50

3.00±n/a nM

Citation

Chen, Y; Masuda, E; Lamagna, C BICYCLIC INHIBITORS OF IRAK US Patent US20230391748 Publication Date 12/7/2023

More Info.:

Get all data from this article, Assay Method

Interleukin-1 receptor-associated kinase 4

Name:

Interleukin-1 receptor-associated kinase 4

Synonyms:

Type:

Protein

Mol. Mass.:

51519.08

Organism:

Homo sapiens (Human)

Description:

Q9NWZ3

Residue:

460

Sequence:

MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS

BDBM639251

n/a

Name

BDBM639251

Synonyms:

1-(((S)-4,4-difluoro-5-oxopyrrolidin-2-yl)methoxy)-4-(1-(cis-3-(dimethylamino)cyclobutyl)-1H-pyrazol-4-yl)-7-isopropoxyisoquinoline-6-carboxamide | US20230391748, Compound I-73

Type

Small organic molecule

Emp. Form.

C27H32F2N6O4

Mol. Mass.

542.5776

SMILES

CC(C)Oc1cc2c(OC[C@@H]3CC(F)(F)C(=O)N3)ncc(-c3cnn(c3)[C@@H]3C[C@@H](C3)N(C)C)c2cc1C(N)=O |r,wU:10.9,26.27,28.32,(4.85,5.94,;4.08,4.6,;4.85,3.27,;2.54,4.6,;1.77,3.27,;2.54,1.94,;1.77,.6,;2.54,-.73,;4.08,-.73,;4.85,-2.07,;6.39,-2.07,;7.29,-3.31,;8.76,-2.84,;10.25,-3.23,;9.53,-4.17,;8.76,-1.3,;10.09,-.53,;7.29,-.82,;1.77,-2.07,;.23,-2.07,;-.54,-.73,;-2.08,-.73,;-2.99,.51,;-4.45,.04,;-4.45,-1.5,;-2.99,-1.98,;-5.78,-2.27,;-7.27,-1.87,;-7.67,-3.36,;-6.18,-3.76,;-8.76,-4.45,;-10.25,-4.05,;-8.36,-5.94,;.23,.6,;-.54,1.94,;.23,3.27,;-.54,4.6,;.23,5.94,;-2.08,4.6,)|

Structure