Ki Summary

Reaction Details

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Target

Interleukin-1 receptor-associated kinase 4

Ligand

BDBM639256

Substrate/Competitor

n/a

Meas. Tech.

IRAK4 ADP-Glo Assay

IC50

3.60±n/a nM

Citation

Chen, Y; Masuda, E; Lamagna, C BICYCLIC INHIBITORS OF IRAK US Patent US20230391748 Publication Date 12/7/2023

More Info.:

Get all data from this article, Assay Method

Interleukin-1 receptor-associated kinase 4

Name:

Interleukin-1 receptor-associated kinase 4

Synonyms:

Type:

Protein

Mol. Mass.:

51519.08

Organism:

Homo sapiens (Human)

Description:

Q9NWZ3

Residue:

460

Sequence:

MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS

BDBM639256

n/a

Name

BDBM639256

Synonyms:

1-(((S)-4,4-difluoro-5-oxopyrrolidin-2-yl)methoxy)-4-(1-((1r,4S)-4-hydroxy-4-methylcyclohexyl)-1H-pyrazol-4-yl)-7-isopropoxyisoquinoline-6-carboxamide | US20230391748, Compound I-78

Type

Small organic molecule

Emp. Form.

C28H33F2N5O5

Mol. Mass.

557.5889

SMILES

CC(C)Oc1cc2c(OC[C@@H]3CC(F)(F)C(=O)N3)ncc(-c3cnn(c3)[C@H]3CC[C@](C)(O)CC3)c2cc1C(N)=O |r,wU:10.9,26.27,29.31,wD:29.32,(4.45,5.94,;3.68,4.6,;4.45,3.27,;2.14,4.6,;1.37,3.27,;2.14,1.94,;1.37,.6,;2.14,-.73,;3.68,-.73,;4.45,-2.07,;5.99,-2.07,;6.9,-3.31,;8.36,-2.84,;9.85,-3.23,;9.13,-4.17,;8.36,-1.3,;9.69,-.53,;6.9,-.82,;1.37,-2.07,;-.17,-2.07,;-.94,-.73,;-2.48,-.73,;-3.38,.51,;-4.85,.04,;-4.85,-1.5,;-3.38,-1.98,;-6.18,-2.27,;-5.78,-3.76,;-6.87,-4.85,;-8.36,-4.45,;-8.76,-5.94,;-9.85,-4.85,;-8.76,-2.96,;-7.67,-1.87,;-.17,.6,;-.94,1.94,;-.17,3.27,;-.94,4.6,;-.17,5.94,;-2.48,4.6,)|

Structure