Ki Summary

Reaction Details

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Target

Interleukin-1 receptor-associated kinase 4

Ligand

BDBM639281

Substrate/Competitor

n/a

Meas. Tech.

IRAK4 ADP-Glo Assay

IC50

3.20±n/a nM

Citation

Chen, Y; Masuda, E; Lamagna, C BICYCLIC INHIBITORS OF IRAK US Patent US20230391748 Publication Date 12/7/2023

More Info.:

Get all data from this article, Assay Method

Interleukin-1 receptor-associated kinase 4

Name:

Interleukin-1 receptor-associated kinase 4

Synonyms:

Type:

Protein

Mol. Mass.:

51519.08

Organism:

Homo sapiens (Human)

Description:

Q9NWZ3

Residue:

460

Sequence:

MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS

BDBM639281

n/a

Name

BDBM639281

Synonyms:

1-(((R)-1-(2-cyanoacetyl)piperidin-3-yl)oxy)-4-((cis-3-(dimethylamino)cyclobutyl)ethynyl)-7-isopropoxyisoquinoline-6-carboxamide | US20230391748, Compound I-106

Type

Small organic molecule

Emp. Form.

C29H35N5O4

Mol. Mass.

517.6193

SMILES

CC(C)Oc1cc2c(O[C@@H]3CCCN(C3)C(=O)CC#N)ncc(C#C[C@H]3C[C@H](C3)N(C)C)c2cc1C(N)=O |r,wU:9.8,25.25,27.30,(3.4,5.33,;2.63,4,;3.4,2.67,;1.09,4,;.32,2.67,;1.09,1.33,;.32,,;1.09,-1.33,;2.63,-1.33,;3.4,-2.67,;2.63,-4,;3.4,-5.33,;4.94,-5.33,;5.71,-4,;4.94,-2.67,;7.25,-4,;8.02,-2.67,;8.02,-5.33,;9.56,-5.33,;11.1,-5.33,;.32,-2.67,;-1.22,-2.67,;-1.99,-1.33,;-3.53,-1.33,;-5.07,-1.33,;-6.61,-1.33,;-7.7,-2.42,;-8.79,-1.33,;-7.7,-.24,;-10.33,-1.33,;-11.1,-2.67,;-11.1,,;-1.22,,;-1.99,1.33,;-1.22,2.67,;-1.99,4,;-1.22,5.33,;-3.53,4,)|

Structure