| Reaction Details |
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 | Report a problem with these data |
| Target | Interleukin-1 receptor-associated kinase 4 |
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| Ligand | BDBM643763 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Potency of IRAK4 Inhibitor Compounds in IRAK4 Enzyme Assay |
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| IC50 | <0.500±n/a nM |
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| Citation |  Terstiege, I; Schiesser, S; Xue, Y; Chang, H; Berggren, AI Substituted indazoles as IRAK4 inhibitors US Patent US11866405 Publication Date 1/9/2024 |
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| More Info.: | Get all data from this article, Assay Method |
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| Interleukin-1 receptor-associated kinase 4 |
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| Name: | Interleukin-1 receptor-associated kinase 4 |
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| Synonyms: | IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64 |
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| Type: | Protein |
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| Mol. Mass.: | 51519.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NWZ3 |
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| Residue: | 460 |
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| Sequence: | MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
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| BDBM643763 |
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| n/a |
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| Name | BDBM643763 |
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| Synonyms: | US11866405, Example 64 | US11866405, Example 65 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H29N7O3 |
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| Mol. Mass. | 487.5536 |
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| SMILES | COc1cc2nn(cc2cc1C(=O)Nc1cnc2cccnn12)[C@@H]1CC[C@]2(CN(C2)C(C)=O)C[C@@H]1C |r| |
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| Structure | 
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