Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Interleukin-1 receptor-associated kinase 4 | ||
| Ligand | BDBM643768 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Potency of IRAK4 Inhibitor Compounds in IRAK4 Enzyme Assay | ||
| IC50 | <0.300±n/a nM | ||
| Citation |  Terstiege, I; Schiesser, S; Xue, Y; Chang, H; Berggren, AI Substituted indazoles as IRAK4 inhibitors US Patent US11866405 Publication Date 1/9/2024 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Interleukin-1 receptor-associated kinase 4 | |||
| Name: | Interleukin-1 receptor-associated kinase 4 | ||
| Synonyms: | IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64 | ||
| Type: | Protein | ||
| Mol. Mass.: | 51519.08 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q9NWZ3 | ||
| Residue: | 460 | ||
| Sequence: |
| ||
| BDBM643768 | |||
| n/a | |||
| Name | BDBM643768 | ||
| Synonyms: | US11866405, Example 4 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H27N7O3 | ||
| Mol. Mass. | 461.5163 | ||
| SMILES | COc1cc2nn(cc2cc1C(=O)Nc1cnc2cccnn12)[C@H]1CC[C@@H](CC1)C(=O)N(C)C |r,wU:26.33,wD:23.26,(3.88,-3.24,;3.88,-1.7,;2.54,-.93,;1.21,-1.7,;-.12,-.93,;-1.59,-1.4,;-2.49,-.16,;-1.59,1.09,;-.12,.61,;1.21,1.38,;2.54,.61,;3.88,1.38,;3.88,2.92,;5.21,.61,;6.54,1.38,;6.71,2.92,;8.21,3.24,;8.98,1.9,;10.49,1.58,;10.96,.12,;9.93,-1.03,;8.43,-.71,;7.95,.76,;-4.03,-.16,;-4.8,1.18,;-6.34,1.18,;-7.11,-.16,;-6.34,-1.49,;-4.8,-1.49,;-8.65,-.16,;-9.42,1.18,;-9.42,-1.49,;-8.65,-2.82,;-10.96,-1.49,)| | ||
| Structure | 
| ||