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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Interleukin-1 receptor-associated kinase 4 | ||
| Ligand | BDBM643773 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Potency of IRAK4 Inhibitor Compounds in IRAK4 Enzyme Assay | ||
| IC50 | 0.500±n/a nM | ||
| Citation |  Terstiege, I; Schiesser, S; Xue, Y; Chang, H; Berggren, AI Substituted indazoles as IRAK4 inhibitors US Patent US11866405 Publication Date 1/9/2024 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Interleukin-1 receptor-associated kinase 4 | |||
| Name: | Interleukin-1 receptor-associated kinase 4 | ||
| Synonyms: | IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64 | ||
| Type: | Protein | ||
| Mol. Mass.: | 51519.08 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q9NWZ3 | ||
| Residue: | 460 | ||
| Sequence: |
| ||
| BDBM643773 | |||
| n/a | |||
| Name | BDBM643773 | ||
| Synonyms: | US11866405, Example 69 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H27N7O3 | ||
| Mol. Mass. | 473.527 | ||
| SMILES | COc1cc2nn(cc2cc1C(=O)Nc1cnc2cccnn12)[C@H]1CC[C@]2(CN(C)C(=O)C2)CC1 |r,wU:23.26,wD:26.30,(3.8,-3.24,;3.8,-1.7,;2.47,-.93,;1.14,-1.7,;-.2,-.93,;-1.66,-1.4,;-2.57,-.16,;-1.66,1.09,;-.2,.61,;1.14,1.38,;2.47,.61,;3.8,1.38,;3.8,2.92,;5.14,.61,;6.47,1.38,;6.63,2.92,;8.14,3.24,;8.91,1.9,;10.42,1.58,;10.89,.12,;9.86,-1.03,;8.35,-.71,;7.88,.76,;-4.11,-.16,;-4.88,-1.49,;-6.42,-1.49,;-7.19,-.16,;-8.09,1.09,;-9.56,.61,;-10.89,1.38,;-9.56,-.93,;-10.65,-2.01,;-8.09,-1.4,;-6.42,1.18,;-4.88,1.18,)| | ||
| Structure | 
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