Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Interleukin-1 receptor-associated kinase 4 | ||
Ligand | BDBM643792 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Potency of IRAK4 Inhibitor Compounds in IRAK4 Enzyme Assay | ||
IC50 | 0.600±n/a nM | ||
Citation | Terstiege, I; Schiesser, S; Xue, Y; Chang, H; Berggren, AI Substituted indazoles as IRAK4 inhibitors US Patent US11866405 Publication Date 1/9/2024 | ||
More Info.: | Get all data from this article, Assay Method | ||
Interleukin-1 receptor-associated kinase 4 | |||
Name: | Interleukin-1 receptor-associated kinase 4 | ||
Synonyms: | IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64 | ||
Type: | Protein | ||
Mol. Mass.: | 51519.08 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q9NWZ3 | ||
Residue: | 460 | ||
Sequence: |
| ||
BDBM643792 | |||
n/a | |||
Name | BDBM643792 | ||
Synonyms: | US11866405, Example 16 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H30N6O3 | ||
Mol. Mass. | 486.5655 | ||
SMILES | CC1(O)C[C@@]2(C1)CC[C@@H](CC2)n1cc2cc(C(=O)Nc3cnn4cccnc34)c(OC3CC3)cc2n1 |r,wU:8.12,4.4,(-10.67,7.99,;-9.58,6.9,;-10.67,5.81,;-8.49,5.81,;-7.41,6.9,;-8.49,7.99,;-6.64,5.56,;-5.1,5.56,;-4.33,6.9,;-5.1,8.23,;-6.64,8.23,;-2.79,6.9,;-1.88,8.14,;-.42,7.67,;.92,8.44,;2.25,7.67,;3.59,8.44,;3.59,9.98,;4.92,7.67,;6.25,8.44,;6.41,9.97,;7.92,10.29,;8.69,8.95,;10.2,8.63,;10.67,7.17,;9.64,6.03,;8.14,6.35,;7.66,7.81,;2.25,6.13,;3.59,5.36,;3.59,3.82,;2.82,2.48,;4.36,2.48,;.92,5.36,;-.42,6.13,;-1.88,5.65,)| | ||
Structure |