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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Interleukin-1 receptor-associated kinase 4 | ||
| Ligand | BDBM643827 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Potency of IRAK4 Inhibitor Compounds in IRAK4 Enzyme Assay | ||
| IC50 | 0.500±n/a nM | ||
| Citation |  Terstiege, I; Schiesser, S; Xue, Y; Chang, H; Berggren, AI Substituted indazoles as IRAK4 inhibitors US Patent US11866405 Publication Date 1/9/2024 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Interleukin-1 receptor-associated kinase 4 | |||
| Name: | Interleukin-1 receptor-associated kinase 4 | ||
| Synonyms: | IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64 | ||
| Type: | Protein | ||
| Mol. Mass.: | 51519.08 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q9NWZ3 | ||
| Residue: | 460 | ||
| Sequence: |
| ||
| BDBM643827 | |||
| n/a | |||
| Name | BDBM643827 | ||
| Synonyms: | US11866405, Example 96 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H29N7O3 | ||
| Mol. Mass. | 487.5536 | ||
| SMILES | COc1cc2nn(cc2cc1C(=O)Nc1cnn2cccnc12)[C@H]1CC[C@@H](CC1)N(C)C(=O)C1CC1 |r,wU:23.26,wD:26.33,(4.54,-3.24,;4.54,-1.7,;3.21,-.93,;1.88,-1.7,;.54,-.93,;-.92,-1.4,;-1.83,-.16,;-.92,1.09,;.54,.61,;1.88,1.38,;3.21,.61,;4.54,1.38,;4.54,2.92,;5.88,.61,;7.21,1.38,;7.37,2.92,;8.88,3.24,;9.65,1.9,;11.15,1.58,;11.63,.12,;10.6,-1.03,;9.09,-.71,;8.62,.76,;-3.37,-.16,;-4.14,-1.49,;-5.68,-1.49,;-6.45,-.16,;-5.68,1.18,;-4.14,1.18,;-7.99,-.16,;-8.76,1.18,;-8.76,-1.49,;-7.99,-2.82,;-10.3,-1.49,;-11.63,-.72,;-11.63,-2.26,)| | ||
| Structure | 
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